OR4A15 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is a TRPV1 receptor agonist that can lead to desensitization of sensory neurons and reduced neurotransmitter release. As OR4A15 is a G-protein-coupled receptor potentially involved in olfactory signal transduction, capsaicin-induced desensitization of sensory pathways can indirectly inhibit OR4A15 by decreasing overall sensory neuron activity. | ||||||
Lidocaine | 137-58-6 | sc-204056 sc-204056A | 50 mg 1 g | $50.00 $128.00 | ||
Lidocaine is a sodium channel blocker that leads to the suppression of neuronal excitability. By blocking sodium channels, lidocaine can reduce action potential propagation in sensory neurons, which can indirectly inhibit OR4A15's activity by reducing the potential for olfactory signal transduction. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A disrupts protein transport by inhibiting the ADP-ribosylation factor, which is essential for vesicle formation in the Golgi apparatus. This disruption can lead to reduced membrane expression of G-protein-coupled receptors such as OR4A15, thereby inhibiting its functional activity. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $117.00 $357.00 $928.00 | 17 | |
Concanavalin A is a lectin that can agglutinate cells and cross-link glycoproteins. Cross-linking of membrane glycoproteins can lead to internalization or downregulation of surface receptors, including G-protein-coupled receptors like OR4A15, resulting in decreased functional activity. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Ouabain is an inhibitor of the Na+/K+-ATPase pump, which is crucial for maintaining ionic gradients across the cell membrane. Inhibition of this pump can alter neuronal excitability, potentially leading to reduced signaling through neurons expressing OR4A15. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is an antagonist of various calcium channels and the ryanodine receptor. By inhibiting calcium influx and intracellular calcium release, it can decrease neuronal excitability and neurotransmitter release, which can indirectly inhibit OR4A15 if it is expressed in neurons that rely on calcium-mediated signaling. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to function as a lysosomotropic agent that can raise the pH of lysosomes and inhibit lysosomal enzymes. This can affect the post-translational modification of proteins, including G-protein-coupled receptors like OR4A15, leading to decreased functional activity through altered processing and trafficking. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $80.00 $275.00 | ||
Dihydro-β-erythroidine is a nicotinic acetylcholine receptor antagonist. By inhibiting these receptors, it can reduce acetylcholine-mediated neuronal excitation. As OR4A15 could be expressed in acetylcholine-responsive neurons, this inhibition can indirectly reduce the functional activity of OR4A15. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased cAMP levels. While typically associated with the activation of cAMP-dependent pathways, forskolin can lead to the desensitization of G-protein-coupled receptors, including OR4A15, through cAMP-mediated feedback inhibition. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $40.00 | 4 | |
Phenylarsine Oxide is an inhibitor of thiol-reactive processes and can interfere with protein folding and trafficking. | ||||||