OR2T35 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red is known to block calcium channels. By inhibiting calcium channels, it decreases intracellular calcium levels, which are crucial for the function of olfactory receptors, including olfactory receptor 2T35, as calcium is involved in the olfactory signal transduction pathway. This results in the inhibition of olfactory receptor 2T35 activity by impairing signal amplification. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine, a TRPV1 antagonist, inhibits the transient receptor potential cation channel subfamily V member 1. This channel is involved in the detection of chemical stimuli that can activate sensory neurons. Inhibiting TRPV1 can dampen the signaling pathways that olfactory receptor 2T35 may rely on for initiating olfactory signal transduction, leading to its functional inhibition. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is a known blocker of various ion channels, including potassium channels. By inhibiting potassium channels, it affects the repolarization phase of the action potential in neurons. This inhibition can alter the signaling pathway of olfactory receptor 2T35 by affecting the electrical activity necessary for its proper function, thus inhibiting its activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA/AM is a cell-permeable calcium chelator that effectively lowers intracellular calcium levels. Since calcium plays a pivotal role in the signal transduction mechanism of olfactory receptors, including olfactory receptor 2T35, chelating intracellular calcium can lead to the inhibition of this receptor's signaling pathways, thereby inhibiting its functional activity. | ||||||
Methyllycaconitine citrate | 112825-05-5 | sc-253043 sc-253043A | 5 mg 25 mg | $117.00 $398.00 | 2 | |
Methyllycaconitine is an antagonist of the nicotinic acetylcholine receptor. Although not directly related to olfactory receptors, by inhibiting nicotinic acetylcholine receptors, it can indirectly influence the neuronal excitability and neurotransmitter release affecting the olfactory system. This can lead to reduced activation of olfactory receptor 2T35, resulting in its functional inhibition. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SK&F 96365 inhibits receptor-mediated calcium entry channels, including TRPC channels. Since TRPC channels are involved in the calcium signaling pathway important for olfactory receptor function, inhibiting these channels can decrease the activity of olfactory receptor 2T35 by preventing calcium-mediated signal transduction. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride selectively inhibits epithelial sodium channels (ENaC). By inhibiting ENaC, it reduces sodium influx, which is necessary for depolarization and the initiation of action potentials in olfactory sensory neurons. This inhibition can indirectly lead to the functional inhibition of olfactory receptor 2T35 by impairing olfactory signal transmission. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $88.00 | ||
Lanthanum(III) chloride is a blocker of calcium channels. By blocking calcium channels, it inhibits calcium influx into cells, which is critical for the signaling processes of many receptors, including olfactory receptors. This inhibition of calcium signaling pathways leads to the functional inhibition of olfactory receptor 2T35 by impairing its ability to participate in olfactory signal transduction. | ||||||