OR2T34 Inhibitors
OR2T34 inhibitors are a class of chemical compounds that target and block the activity of OR2T34, an olfactory receptor (OR) from the G-protein-coupled receptor (GPCR) family. OR2T34 is responsible for detecting specific odorant molecules in the olfactory epithelium of the nose, initiating a signal transduction process that ultimately leads to the perception of smell. Upon binding to an odorant, OR2T34 activates a G-protein, which then triggers downstream signaling pathways that result in the generation of electrical signals sent to the brain for odor interpretation. Inhibitors of OR2T34 disrupt this process by preventing the receptor from binding to its ligand or from activating the G-protein, thus interrupting the cascade that leads to olfactory signal transduction.
In addition to its role in olfaction, OR2T34 may be expressed in non-olfactory tissues, as is common with many olfactory receptors, where it could participate in a variety of other cellular processes such as intracellular signaling and cellular communication. By using OR2T34 inhibitors, researchers can investigate the receptor's specific roles beyond its function in odor detection, exploring how its inhibition affects broader biological systems. Blocking OR2T34 allows scientists to study the interactions between this receptor and other molecular pathways, shedding light on how olfactory receptors like OR2T34 contribute to cellular functions outside of the olfactory system. The use of these inhibitors is instrumental in expanding our understanding of olfactory receptors' multifaceted roles in both sensory and non-sensory biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methyllycaconitine citrate | 112825-05-5 | sc-253043 sc-253043A | 5 mg 25 mg | $117.00 $398.00 | 2 | |
Methyllycaconitine inhibits olfactory receptor 2T34 by binding to nicotinic acetylcholine receptors (nAChRs) which are closely associated with the olfactory system. Since nAChRs modulate olfactory signal transduction, their inhibition can disrupt olfactory receptor function, leading to the inhibition of OR2T34 activity. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine directly inhibits olfactory receptor 2T34 by interfering with ion channels that are critical for olfactory signal transduction. Specifically, it blocks potassium channels which are essential for the repolarization phase of the olfactory receptor neuron action potentials, thereby inhibiting OR2T34 function. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red inhibits olfactory receptor 2T34 by blocking calcium channels involved in the olfactory signal pathway. This blockade prevents calcium influx, which is essential for the activation of various intracellular pathways that lead to olfactory receptor activation, thus inhibiting OR2T34 function. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride inhibits olfactory receptor 2T34 by blocking sodium channels and the epithelial sodium channel (ENaC), which are involved in olfactory signal transduction. This inhibition disrupts the ion balance necessary for the activation of OR2T34, leading to its functional inhibition. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine inhibits olfactory receptor 2T34 by blocking transient receptor potential vanilloid (TRPV) channels, which play a role in sensory signal transduction including olfaction. This blockade prevents the sensory signal transduction processes necessary for OR2T34 activation. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $101.00 $155.00 $389.00 $643.00 | 2 | |
SK&F 96365 inhibits olfactory receptor 2T34 by blocking receptor-operated calcium channels (ROCs), thereby inhibiting calcium influx. Calcium plays a crucial role in the activation of signal transduction pathways within olfactory neurons, leading to the inhibition of OR2T34 function. | ||||||
Iberiotoxin | 129203-60-7 | sc-3585 sc-3585A | 10 µg 100 µg | $270.00 $490.00 | 16 | |
Iberiotoxin inhibits olfactory receptor 2T34 by blocking large conductance Ca2+-activated K+ (BK) channels. These channels are involved in the repolarization phase of neuronal action potentials, and their inhibition disrupts signal transduction in olfactory receptor neurons, thereby inhibiting OR2T34. | ||||||
Apamin | 24345-16-2 | sc-200994 sc-200994A | 500 µg 1 mg | $168.00 $280.00 | 7 | |
Apamin inhibits olfactory receptor 2T34 by blocking small conductance Ca2+-activated K+ (SK) channels, which are critical for the modulation of action potentials and neurotransmitter release in olfactory neurons. This blockade inhibits the function of OR2T34 by disrupting normal signal transduction. | ||||||
Hexamethonium bromide | 55-97-0 | sc-205712 sc-205712A | 10 g 25 g | $45.00 $63.00 | ||
Hexamethonium inhibits olfactory receptor 2T34 by acting as a nicotinic acetylcholine receptor antagonist. It specifically blocks the receptor's function, which is essential for the modulation of olfactory signal transduction pathways, thereby leading to the inhibition of OR2T34 activity. | ||||||