Date published: 2025-12-24

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OR2AG1 Inhibitors

OR2AG1 inhibitors encompass a diverse range of chemical compounds that interact with different parts of the olfactory signaling pathway, thereby leading to the inhibition of OR2AG1. Phenylethylamine, for instance, competes with OR2AG1's natural ligands for binding, thus inhibiting the receptor's functional activity. Cinnamaldehyde and carvone work similarly by binding to the receptor's active site or causing allosteric changes that prevent OR2AG1 from being activated. Capsaicin and menthol, on the other hand, indirectly influence OR2AG1 activity by modulating the sensory neuron environment, leading to receptor desensitization or changes in cell membrane properties that impact OR2AG1's functionality. Other inhibitors like chloroform and lidocaine exert their effects by altering the membrane dynamics or ion channel activity, respectively, which can result in a reduced OR2AG1 signal transduction. Compounds such as quinine and copper sulfate might inhibit OR2AG1 through competitive inhibition or by directly binding to the receptor or associated signaling molecules. Ruthenium Red and verapamil target the calcium-dependent processes vital for OR2AG1 signal propagation, thus hindering the receptor's response to its agonists. Lastly, Dihydro-β-erythroidine indirectly affects OR2AG1 signaling by modulating neurotransmitter release in the neurons where OR2AG1 is expressed, highlighting the complex interplay between different neurotransmitter systems and olfactory receptor activity.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$102.00
$224.00
(0)

Cinnamaldehyde interacts with olfactory receptors and has been shown to inhibit some of them. It may inhibit OR2AG1 by binding to its active site, preventing the receptor from interacting with its specific agonists.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$94.00
$173.00
$255.00
$423.00
26
(1)

Capsaicin is an agonist of TRPV1 and can modulate sensory neurons, potentially leading to a decrease in OR2AG1 activity through neuronal desensitization or receptor internalization.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$38.00
$67.00
(0)

Menthol is known to modulate ion channels and G-protein coupled receptors. It may inhibit OR2AG1 indirectly by altering the lipid membrane environment or receptor conformation.

Chloroform

67-66-3sc-239527A
sc-239527
1 L
4 L
$110.00
$200.00
1
(0)

Chloroform can affect membrane fluidity and protein functionality. It may inhibit OR2AG1 by disrupting the receptor's membrane environment, leading to a loss of receptor activity.

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$50.00
$128.00
(0)

Lidocaine alters signal transduction in neurons by blocking sodium channels. This can result in diminished OR2AG1 signaling by preventing action potential propagation in olfactory neurons.

Quinine

130-95-0sc-212616
sc-212616A
sc-212616B
sc-212616C
sc-212616D
1 g
5 g
10 g
25 g
50 g
$77.00
$102.00
$163.00
$347.00
$561.00
1
(0)

Quinine is a bitter compound that interacts with G-protein coupled receptors. It can inhibit OR2AG1 by competing with its agonists or altering G-protein signaling pathways.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$45.00
$120.00
$185.00
3
(1)

Copper ions can bind to receptor proteins and inhibit their function. Copper sulfate may inhibit OR2AG1 by directly interacting with the receptor or its signaling partners.

Ruthenium red

11103-72-3sc-202328
sc-202328A
500 mg
1 g
$184.00
$245.00
13
(1)

Ruthenium Red is known to interact with various ion channels. It could inhibit OR2AG1 by modifying the calcium homeostasis, which is crucial for GPCR signaling.

Verapamil

52-53-9sc-507373
1 g
$367.00
(0)

Verapamil is a calcium channel blocker that can reduce calcium-dependent signaling. Reduced intracellular calcium can inhibit OR2AG1 activity by minimizing G-protein activation.

(+)-Carvone

2244-16-8sc-239480
sc-239480A
5 ml
25 ml
$32.00
$82.00
2
(1)

Carvone interacts with olfactory receptors and can inhibit OR2AG1 by steric hindrance or allosteric modulation, preventing activation by its ligands.