Date published: 2026-5-30

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OR10T2 Inhibitors

Olfactory receptor 10T2 Inhibitors are chemical compounds that attenuate the function of Olfactory receptor 10T2 through modulation of various sensory neuron signaling pathways. Compounds such as icilin and menthol, which are agonists of the TRPM8 channel, can indirectly suppress Olfactory receptor 10T2 by altering calcium homeostasis in olfactory sensory neurons, crucial for olfactory signal transduction. Similarly, capsaicin and eugenol target TRPV1 receptors and can decrease the receptor's activity by causing sensory neuron depolarization and desensitization, leading to modifications in intracellular ion concentrations. Furthermore, metal ions like zinc in Gluconic acid zinc (II) salt and copper in Copper(II) sulfate can bind to Olfactory receptor 10T2 or closely related structures, changing receptor conformation and function, thereby reducing olfactory perception. Additionally, quinine and chloroquine, which are known for influencing taste receptors, may extend their effects to olfactory receptors such as Olfactory receptor 10T2 by altering associated G-protein-coupled receptor pathways. In the context of local anesthetics, lidocaine acts as a sodium channel blocker, decreasing neuronal excitability and thus potentially reducing the activity of Olfactory receptor 10T2 by inhibiting action potentials in olfactory sensory neurons. Ruthenium Red plays a role in blocking calcium channels, which can dampen Olfactory receptor 10T2 function by affecting calcium-dependent signaling pathways that are integral to olfactory perception. Cinnamic Aldehyde and camphor both act as TRPA1 agonists and can modify the neuronal signaling within the olfactory system, which may lead to a reduction in Olfactory receptor 10T2 activity due to altered ionic currents that result in desensitization or other changes in neuron signaling dynamics. These inhibitors, through their targeted actions on specific channels and signaling pathways, collectively contribute to the diminishment of Olfactory receptor 10T2's functional activity, essential for the sense of smell.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Icilin

36945-98-9sc-201557
sc-201557A
10 mg
50 mg
$91.00
$257.00
9
(1)

A supercooling agent that activates TRPM8 channels which can modulate the downstream signaling of olfactory receptors including Olfactory receptor 10T2 by affecting calcium homeostasis in olfactory sensory neurons, leading to a reduction in their functional activity.

Capsaicin

404-86-4sc-3577
sc-3577C
sc-3577D
sc-3577A
50 mg
250 mg
500 mg
1 g
$96.00
$160.00
$240.00
$405.00
26
(1)

An agonist of the TRPV1 receptor, capsaicin causes depolarization and potential desensitization of sensory neurons, which could diminish the sensitivity and activity of Olfactory receptor 10T2 by modifying intracellular ion concentrations.

Eugenol

97-53-0sc-203043
sc-203043A
sc-203043B
1 g
100 g
500 g
$32.00
$62.00
$218.00
2
(1)

A TRPV1 receptor agonist, eugenol can decrease the activity of Olfactory receptor 10T2 by altering the ionic environment of olfactory sensory neurons, and thus diminishing signal transduction processes associated with olfaction.

(±)-Menthol

89-78-1sc-250299
sc-250299A
100 g
250 g
$39.00
$68.00
(0)

Agonist of TRPM8, menthol could indirectly reduce the sensitivity of Olfactory receptor 10T2 by causing transient changes in calcium ion influx in olfactory receptor neurons, thereby impacting olfactory signal transduction.

Zinc

7440-66-6sc-213177
100 g
$48.00
(0)

As a zinc salt, Gluconic acid zinc (II) salt can bind to and modulate various olfactory receptors, potentially leading to a decreased functional activity of Olfactory receptor 10T2 by altering receptor conformation and function.

Copper(II) sulfate

7758-98-7sc-211133
sc-211133A
sc-211133B
100 g
500 g
1 kg
$46.00
$122.00
$189.00
3
(1)

Copper ions have been shown to modulate the activity of olfactory receptors; Copper(II) sulfate could thereby diminish the functional activity of Olfactory receptor 10T2 by binding to receptor sites and altering signal transduction.

Quinine

130-95-0sc-212616
sc-212616A
sc-212616B
sc-212616C
sc-212616D
1 g
5 g
10 g
25 g
50 g
$79.00
$104.00
$166.00
$354.00
$572.00
1
(0)

Known as a bitter compound, quinine can influence taste receptors and may indirectly affect olfactory receptors like Olfactory receptor 10T2 by modifying G-protein coupled receptor pathways in sensory neurons.

Lidocaine

137-58-6sc-204056
sc-204056A
50 mg
1 g
$51.00
$131.00
(0)

As a sodium channel blocker, lidocaine can reduce neuronal excitability. This could lead to a reduction in the activity of Olfactory receptor 10T2 by inhibiting action potentials in olfactory sensory neurons that express this receptor.

Ruthenium red

11103-72-3sc-202328
sc-202328A
500 mg
1 g
$188.00
$250.00
13
(1)

Blocks calcium channels and can indirectly reduce Olfactory receptor 10T2 activity by affecting calcium-dependent signaling pathways in olfactory neurons, thus dampening olfactory perception.

Cinnamic Aldehyde

104-55-2sc-294033
sc-294033A
100 g
500 g
$104.00
$228.00
(0)

A TRPA1 agonist, Cinnamic Aldehyde could reduce the activity of Olfactory receptor 10T2 by activating sensory neurons in a way that leads to desensitization or altered neuronal signaling in the olfactory system.