OR10G4 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Diphenhydramine hydrochloride | 147-24-0 | sc-204729 sc-204729A sc-204729B | 10 g 25 g 100 g | $51.00 $82.00 $122.00 | 4 | |
Diphenhydramine is an H1 histamine receptor antagonist that can reduce intracellular calcium signaling. OR10G4 is postulated to be involved in calcium-mediated neuronal signaling; by decreasing histamine-induced calcium influx, diphenhydramine may indirectly inhibit OR10G4's activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can impede the entry of calcium into cells. Since OR10G4 is implicated in calcium-dependent signaling pathways, verapamil's reduction of intracellular calcium can indirectly inhibit OR10G4 function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine is another calcium channel blocker that acts on L-type calcium channels. By decreasing calcium availability within the cell, nifedipine could suppress OR10G4-associated calcium signaling cascades. | ||||||
Reserpine | 50-55-5 | sc-203370 sc-203370A | 1 g 5 g | $134.00 $406.00 | 1 | |
Reserpine functions as an inhibitor of vesicular monoamine transporters, affecting neurotransmitter release. This could indirectly diminish OR10G4 activity by altering neurotransmitter levels and receptor-mediated signaling. | ||||||
Diltiazem | 42399-41-7 | sc-204726 sc-204726A | 1 g 5 g | $209.00 $464.00 | 4 | |
Diltiazem is a benzothiazepine that blocks calcium channels. Similar to verapamil and nifedipine, by reducing calcium levels in the cell, it may indirectly inhibit the calcium-dependent signaling of OR10G4. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC), which is involved in GPCR signaling pathways. Inhibiting PKC can disrupt downstream signaling from OR10G4. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 is an adenylyl cyclase inhibitor that prevents the conversion of ATP to cAMP. With decreased cAMP levels, the signaling cascades involving OR10G4 can be inhibited. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is known to increase cAMP levels, but paradoxically, it can desensitize GPCR responses through cAMP-dependent protein kinase (PKA) activation, which may result in a long-term inhibition of OR10G4 signaling. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis toxin irreversibly inactivates Gi/Go proteins. If OR10G4 signals through Gi/Go proteins, this would prevent OR10G4-mediated inhibition of adenylate cyclase, thus potentially decreasing OR10G4 signaling. | ||||||