OPA1 Activators
OPA1 (Optic Atrophy 1) activators belong to a distinct chemical class characterized by their ability to modulate the activity of the OPA1 protein. OPA1 is a critical protein primarily located in the inner mitochondrial membrane, where it plays a central role in mitochondrial fusion and maintenance. Mitochondria are the cellular powerhouses responsible for generating energy through oxidative phosphorylation and are essential for various cellular processes. The regulation of mitochondrial dynamics, including fusion and fission, is vital for maintaining mitochondrial health and overall cellular function.
OPA1 activators are small molecules or compounds that have been developed to target the OPA1 protein, enhancing its activity in promoting mitochondrial fusion. By modulating OPA1, these activators contribute to the maintenance of healthy mitochondria, ensuring efficient energy production and mitigating the detrimental effects of mitochondrial dysfunction. Proper mitochondrial fusion mediated by OPA1 is essential for maintaining mitochondrial integrity, preventing the accumulation of damaged mitochondria, and safeguarding against cellular stress. The activation of OPA1 by these compounds represents a promising avenue of research in the field of cellular biology and mitochondrial function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mitochondrial Fusion Promoter M1 | 219315-22-7 | sc-507151 | 25 mg | $134.00 | ||
M1 is a small molecule compound that has shown promise in promoting mitochondrial fusion by activating OpaIt works by increasing Opa1 protein levels, thereby enhancing the fusion of healthy mitochondria. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $204.00 $459.00 $714.00 $1224.00 | 10 | |
Urolithin A is a natural compound found in ellagic acid found in pomegranates and other fruits. It has been shown to activate Opa1 and promote mitochondrial fusion, which may have benefits for overall mitochondrial health. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
Integrated Stress Response Inhibitor (ISRIB) is a compound that has been studied for its ability to enhance mitochondrial fusion, including Opa1-mediated fusion. It may help protect against cellular stressors. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Sodium valproate is an agent in research used to treat epilepsy and bipolar disorder. Studies have suggested that it can activate Opa1 and promote mitochondrial fusion, potentially contributing to its therapeutic effects. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol found in red wine, grapes, and certain berries. It has been investigated for its potential to activate Opa1 and improve mitochondrial function, which may have various health benefits. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea known for its antioxidant properties. It has been investigated for its potential to activate Opa1 and improve mitochondrial function. | ||||||