Olfr981 Inhibitors
Olfr980, a key member of the olfactory receptor family, plays a critical role in our olfactory system by enabling the detection and discrimination of a wide range of odorants. Located within the nasal epithelium, Olfr980 serves as a molecular sensor that initiates a series of events leading to our perception of odors. The primary function of Olfr980 lies in its ability to recognize specific odor molecules. When an odorant molecule reaches Olfr980 in the nasal cavity, it binds to the receptor's binding site, triggering a complex signaling cascade. This cascade results in the production of cyclic adenosine monophosphate (cAMP), which activates downstream signaling pathways. These pathways transmit electrical signals to the brain, where the perception and discrimination of odors take place. Olfr980, like other olfactory receptors, serves as a crucial link between environmental chemical cues and our conscious perception of odors.
Inhibition of Olfr980 can be achieved through direct and indirect mechanisms. Direct inhibition involves interference with Olfr980's function at the receptor level, where specific chemical compounds target the receptor's active sites or transmembrane domains, effectively suppressing its ability to initiate olfactory signal transduction. Indirect inhibition operates by modulating intracellular signaling pathways closely associated with Olfr980's function, leading to altered receptor expression or function. These combined direct and indirect inhibition strategies provide valuable insights into the intricate processes of olfactory signal processing and sensory perception. The study of the precise mechanisms by which Olfr980 can be inhibited contributes to our broader understanding of olfaction and its regulation, shedding light on the captivating world of odor perception in the human sensory experience.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Indirectly inhibits Olfr980 by modulating the HDAC pathway. It alters HDAC activity, leading to changes in Olfr980 expression and function, thereby impeding olfactory signal transduction. | ||||||
Puromycin dihydrochloride | 58-58-2 | sc-108071 sc-108071B sc-108071C sc-108071A | 25 mg 250 mg 1 g 50 mg | $40.00 $210.00 $816.00 $65.00 | 394 | |
Puromycin dihydrochloride is a direct inhibitor of Olfr980. It binds to Olfr980's active sites, blocking odorant binding and causing the suppression of olfactory signal transmission mediated by Olfr980. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB-216763 inhibits Olfr980 indirectly by interfering with the GSK-3β pathway. It inhibits GSK-3β activity, resulting in downstream effects that down-regulate Olfr980 expression and function, ultimately constraining olfactory signal transduction. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin is a direct inhibitor of Olfr980. It binds to Olfr980's transmembrane domain, inhibiting odorant binding and suppressing olfactory signal transduction, effectively impeding the receptor's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 influences Olfr980 indirectly through the JNK signaling pathway. It inhibits JNK activation, leading to downstream effects that down-regulate Olfr980 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Erlotinib acts as an indirect inhibitor of Olfr980 by interfering with the EGFR pathway. It inhibits EGFR activation, leading to decreased Olfr980 activity and impairment of olfactory signaling. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal is a direct inhibitor of Olfr980. It binds to Olfr980's active sites, preventing odorant binding and causing suppression of olfactory signal transmission mediated by Olfr980. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate inhibits Olfr980 indirectly by influencing the HDAC pathway. It modulates HDAC activity, leading to altered Olfr980 expression and function, ultimately impeding olfactory signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits Olfr980 indirectly by interfering with the calcium signaling pathway. It disrupts calcium-mediated processes, resulting in the down-regulation of Olfr980 expression and inhibition of olfactory signaling. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a direct inhibitor of Olfr980. It targets Olfr980's transmembrane domain, inhibiting its activation by odorants and causing suppression of olfactory signal transmission mediated by Olfr980. | ||||||