Olfr889 Activators
Olfr889 is an olfactory receptor protein responsible for detecting and transducing odorant signals, allowing us to perceive and differentiate various scents in our environment. Activation of Olfr889 involves a complex interplay of chemicals and signaling pathways that collectively contribute to its functional role in odor detection. The primary function of Olfr889 is to recognize and respond to specific odorants. When an odorant molecule binds to Olfr889, it undergoes a conformational change that activates the receptor. This activation can occur through direct binding of chemicals like Capsaicin and Benzaldehyde to Olfr889's receptor site, or indirectly through the modulation of intracellular pathways like the cAMP-dependent PKA pathway by chemicals like Forskolin and 8-Br-cAMP.
Indirect activators, such as Retinoic acid and Resveratrol, influence Olfr889 by up-regulating its expression through specific signaling pathways. These chemicals enhance the synthesis of Olfr889 protein, resulting in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. In summary, Olfr889 plays a crucial role in our sense of smell, and its activation is orchestrated by a diverse range of chemicals that either directly or indirectly enhance its responsiveness to odorants, allowing us to perceive and distinguish various scents in our environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate directly activates Olfr889 by binding to its receptor site, inducing a conformational change that triggers intracellular signaling cascades through G-proteins, ultimately leading to the functional activation of Olfr889 in olfactory signal transduction. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose influences Olfr889 activation through the glycolytic pathway. It modulates glucose metabolism, indirectly enhancing olfactory receptor expression, leading to an amplification of the receptor's response to odorant molecules and functional activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is an indirect activator of Olfr889. It influences the retinoic acid receptor signaling pathway, which in turn up-regulates Olfr889 expression by binding to retinoic acid response elements in its promoter region. This results in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin directly activates Olfr889 by binding to its receptor site, initiating a conformational change that triggers intracellular signaling cascades through G-proteins. This leads to the functional activation of Olfr889 in olfactory signal transduction. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates Olfr889 by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. This leads to elevated intracellular calcium levels, which enhance olfactory receptor sensitivity and promote the functional activation of Olfr889 in response to odorants. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) indirectly activates Olfr889 by mimicking cAMP. It enhances cAMP-dependent protein kinase (PKA) phosphorylation of olfactory receptors, amplifying their sensitivity to odorants and promoting the functional activation of Olfr889 in odor detection. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol indirectly activates Olfr889 by influencing the SIRT1 signaling pathway. It up-regulates the expression of SIRT1, which in turn leads to increased Olfr889 expression. This results in an enhanced number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram indirectly activates Olfr889 by inhibiting phosphodiesterase 4 (PDE4), leading to elevated intracellular cAMP levels. This enhances cAMP-dependent protein kinase (PKA) phosphorylation of olfactory receptors, amplifying their sensitivity to odorants and promoting the functional activation of Olfr889 in odor detection. | ||||||
Iodoacetic acid | 64-69-7 | sc-215183 sc-215183A | 10 g 25 g | $57.00 $99.00 | ||
Iodoacetic acid influences Olfr889 activation through the glycolytic pathway. It modulates glycolysis, indirectly enhancing olfactory receptor expression, leading to an amplification of the receptor's response to odorant molecules and functional activation. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $385.00 $2654.00 | ||
Vitamin A is an indirect activator of Olfr889. It influences the retinoic acid receptor signaling pathway, which in turn up-regulates Olfr889 expression by binding to retinoic acid response elements in its promoter region. This results in an increased number of active receptors on the cell membrane and functional enhancement of odorant sensitivity. | ||||||