Olfr887 Inhibitors
Olfr887, as a member of the olfactory receptor family, plays a crucial role in the detection and signaling of odorant molecules. These receptors are a subset of the G-protein-coupled receptor (GPCR) family, which are integral in the perception of smell. Activation of Olfr887 by specific odorants triggers a cascade of intracellular events, primarily involving the activation of G proteins and subsequent signaling pathways that convert chemical signals into neuronal responses.
Given the specificity and complexity of olfactory receptors, direct inhibitors are challenging to identify. Therefore, the approach for inhibiting Olfr887 is often indirect, targeting the signaling pathways and cellular processes that influence the receptor's function. The focus is typically on the modulation of second messenger systems, such as cyclic AMP (cAMP), or the interaction with other neurotransmitter systems that share signaling components with olfactory receptors. The inhibitors listed in the table primarily consist of beta-adrenergic receptor antagonists. By decreasing cAMP levels within olfactory sensory neurons, these compounds can reduce the responsiveness of the GPCRs to their specific ligands, including Olfr887.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metoprolol Tartrate | 56392-17-7 | sc-205751 sc-205751A | 5 g 25 g | $105.00 $238.00 | 3 | |
Metoprolol, a beta-1 adrenergic receptor antagonist, indirectly affects Olfr887 by reducing cAMP levels in olfactory sensory neurons, thus potentially modulating GPCR-mediated signaling associated with olfactory receptors. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol, a non-selective beta-adrenergic antagonist, can indirectly inhibit Olfr887 by decreasing intracellular cAMP levels, a crucial component for GPCR signaling in olfactory neurons. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $122.00 $235.00 $520.00 $979.00 $1500.00 | 2 | |
Carvedilol, with its beta-adrenergic antagonism and alpha-blocking effects, may indirectly inhibit Olfr887 by affecting neurotransmitter dynamics, thus influencing GPCR signaling in the olfactory system. | ||||||
Nadolol | 42200-33-9 | sc-253175 | 1 g | $180.00 | ||
Nadolol, a non-selective beta-adrenergic receptor antagonist, potentially inhibits Olfr887 by reducing cAMP levels in olfactory sensory neurons, impacting GPCR-mediated signaling. | ||||||
Labetalol | 36894-69-6 | sc-484723 | 50 mg | $176.00 | ||
Labetalol, a mixed alpha/beta adrenergic antagonist, could indirectly inhibit Olfr887 by modulating neurotransmitter release and receptor sensitivity, thereby affecting GPCR signaling pathways in olfaction. | ||||||
(RS)-Atenolol | 29122-68-7 | sc-204895 sc-204895A | 1 g 10 g | $77.00 $408.00 | 1 | |
Atenolol, a selective beta-1 adrenergic receptor antagonist, indirectly inhibits Olfr887 by affecting cAMP levels within olfactory neurons, thus impacting GPCR-mediated signaling processes. | ||||||
Esmolol Hydrochloride | 81161-17-3 | sc-211424 | 10 mg | $149.00 | 1 | |
Esmolol, a beta-1 adrenergic antagonist, can indirectly affect Olfr887 by modulating cAMP levels, leading to altered GPCR signaling in olfactory sensory neurons. | ||||||
Bisoprolol | 66722-44-9 | sc-278792 | 25 mg | $204.00 | ||
Bisoprolol, a selective beta-1 adrenergic receptor antagonist, may indirectly inhibit Olfr887 by influencing cAMP levels in olfactory neurons, affecting GPCR-mediated signaling. | ||||||
Nebivolol | 99200-09-6 | sc-279910 | 100 mg | $803.00 | 1 | |
Nebivolol, with beta-1 antagonism and vasodilatory effects, could indirectly inhibit Olfr887 by modulating GPCR signaling pathways through alterations in cAMP levels. | ||||||
Sotalol hydrochloride | 959-24-0 | sc-203699 sc-203699A | 10 mg 50 mg | $67.00 $246.00 | 3 | |
Sotalol, as a beta-adrenergic antagonist and potassium channel blocker, may indirectly inhibit Olfr887 by altering intracellular ion dynamics and cAMP levels, affecting GPCR signaling. | ||||||