Olfr854 Activators
Olfr854 is an olfactory receptor gene that encodes a protein part of the G protein-coupled receptor (GPCR) family, instrumental in the detection of odorous compounds. Located in the olfactory epithelium, receptors like Olfr854 are crucial for converting chemical signals from odorants into electrical signals, which are interpreted by the brain as distinct smells. Activation of Olfr854 involves the direct binding of specific odorant molecules, a process vital for triggering a conformational change in the receptor. This change activates the associated G protein, leading to a cascade of intracellular signaling events. Typically, this involves the stimulation of adenylate cyclase, which converts ATP to cyclic AMP (cAMP). Elevated cAMP levels activate protein kinase A (PKA), phosphorylating various cellular targets and resulting in the opening of ion channels. This influx of ions generates an electrical signal, which is transmitted to the brain and perceived as a specific odor.
The specificity of Olfr854's activation is determined by the structural compatibility between the receptor and the odorant molecule. The chemicals listed in the table have been chosen for their potential to fit into the active site of Olfr854, thereby directly activating the receptor through a lock-and-key mechanism. This direct interaction is critical for the functional activation of Olfr854, initiating the olfactory signaling cascade essential for the perception of odors. The ability of these chemicals to activate Olfr854 underscores the diversity and complexity of the olfactory system, highlighting the intricate relationship between the chemical structure of odorants and the activation of specific olfactory receptors. The direct activation of Olfr854 by these chemicals demonstrates the receptor's selectivity and its crucial role in the nuanced process of olfaction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate activates Olfr854 by directly binding to its ligand-binding domain, initiating a conformational change in the protein and the olfactory signaling pathway. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate, known for its banana-like odor, can activate Olfr854 by fitting into the receptor binding site, triggering a signal transduction cascade in the olfactory pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, can activate Olfr854 through direct interaction with the receptor site, causing a structural change that leads to the activation of the olfactory signaling pathway. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
Eucalyptol, a monoterpene, activates Olfr854 through direct binding. Its interaction with the olfactory receptor triggers intracellular events, leading to the perception of its characteristic eucalyptus smell. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene, a cyclic terpene, activates Olfr854 by directly binding to the receptor's ligand-binding domain, causing a conformational change and initiating the olfactory signaling cascade. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, an ester of salicylic acid, activates Olfr854 by fitting into its binding pocket, leading to a change in the receptor's conformation and triggering the olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene, a bicyclic monoterpene, activates Olfr854 through direct binding. Its molecular structure allows effective interaction with the receptor, leading to activation and signal transduction in olfactory neurons. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, a phenolic aldehyde, activates Olfr854 through direct interaction. This compound fits into the receptor's binding site, causing a structural change that leads to olfactory signal activation. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, a ketone with a sweet smell, activates Olfr854 through direct binding, causing a conformational change in the receptor and initiating a specific signaling pathway for olfactory receptors. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, an aldehyde with a grassy odor, activates Olfr854 by directly interacting with the receptor, effectively binding to initiate the olfactory signaling cascade. | ||||||