Olfr825 Activators
Olfr825 is an olfactory receptor belonging to the G protein-coupled receptor (GPCR) family, specialized in detecting a variety of odorant molecules. These receptors are pivotal in the process of olfaction, translating chemical stimuli into neural signals that are perceived as scents by the brain. Olfr825, like other olfactory receptors, is embedded in the olfactory epithelium and plays a crucial role in the detection and discrimination of odorants. The mechanism of activation for Olfr825 involves the direct binding of specific chemical compounds, which are odorants, to the receptor. This interaction results in a conformational change in Olfr825, a critical step in triggering the olfactory signaling cascade. Upon binding of an odorant molecule, Olfr825 undergoes a structural alteration that enables it to activate an associated G protein. The activated G protein then stimulates adenylate cyclase, leading to an increase in the intracellular concentration of cyclic AMP (cAMP). Elevated cAMP levels result in the activation of protein kinase A (PKA), which phosphorylates various targets within the cell. This cascade of events culminates in the opening of ion channels, particularly calcium and sodium channels, leading to depolarization of the olfactory sensory neuron. This depolarization generates an electrical signal that is transmitted to the brain, where it is interpreted as a specific smell.
The chemicals listed in the table have been selected for their potential to directly bind and activate Olfr825. Their structural compatibility with the receptor's binding site allows them to act as effective activators, triggering the receptor's conformational change and subsequent signal transduction. The specificity of this interaction is essential for the selective and precise perception of odors. This direct activation of Olfr825 by these odorants demonstrates the intricate nature of olfactory receptor-ligand interactions, which are fundamental to the sense of smell and the ability to discern a wide range of aromatic compounds.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isobutyl acetate | 110-19-0 | sc-228365 | 25 ml | $36.00 | ||
Isobutyl acetate can activate Olfr825 by directly binding to its ligand-binding domain, leading to a conformational change in the protein and the initiation of the olfactory signaling pathway. | ||||||
Ethyl valerate | 539-82-2 | sc-215002 | 500 ml | $83.00 | ||
Ethyl valerate, known for its fruity aroma, activates Olfr825 through direct interaction with the receptor site. This binding induces a conformational change in the receptor, initiating the olfactory signaling mechanism. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $25.00 $33.00 | ||
Octanal, an aldehyde with a citrus-like odor, activates Olfr825 by directly binding to the receptor, causing a structural change and the subsequent activation of olfactory signaling pathways. | ||||||
Nonanal | 124-19-6 | sc-257926 | 1 g | $66.00 | ||
Nonanal, with its strong citrus scent, activates Olfr825 by binding to the receptor's active site, triggering a conformational change and the initiation of olfactory signal transduction. | ||||||
Decanal | 112-31-2 | sc-234518 | 25 g | $43.00 | ||
Decanal, an aldehyde with a strong citrus odor, activates Olfr825 through direct interaction with the receptor, leading to a change in the receptor's conformation and initiating the olfactory signaling process. | ||||||
Linalool | 78-70-6 | sc-250250 sc-250250A sc-250250B | 5 g 100 g 500 g | $46.00 $71.00 $108.00 | ||
Linalool, a terpene alcohol with a floral scent, activates Olfr825 by interacting directly with the receptor, causing a conformational change and initiating the olfactory signal transduction pathway. | ||||||
(±)-beta-Citronellol | 106-22-9 | sc-294094 sc-294094A | 25 ml 500 ml | $31.00 $153.00 | ||
Citronellol, known for its rose-like aroma, activates Olfr825 by directly binding to the receptor, leading to a conformational change and the activation of olfactory signaling mechanisms. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol, a terpene alcohol found in rose oil, activates Olfr825 by binding to the receptor's active site, triggering a conformational change and the subsequent activation of the olfactory signal transduction pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a component of lemongrass oil, activates Olfr825 through direct interaction with the receptor. This interaction causes a change in the receptor structure, triggering a cascade of intracellular signaling events. | ||||||
cis-3,7-Dimethyl-2,6-octadien-1-ol | 106-25-2 | sc-234382 | 5 ml | $51.00 | ||
cis-3,7-Dimethyl-2,6-octadien-1-ol, a terpene alcohol with a sweet rose-like odor, activates Olfr825 by fitting into its binding pocket, causing a structural change and initiating the olfactory signaling pathway. | ||||||