Olfr732 Inhibitors
Olfr732, a member of the olfactory receptor family 4 subfamily N (OR4N), plays a pivotal role in the olfactory system of Mus musculus (house mouse). Like other olfactory receptors, Olfr732 belongs to the family of G-protein-coupled receptors (GPCRs) characterized by a 7-transmembrane domain structure. Its primary function revolves around the recognition and interaction with odorant molecules within the nasal cavity, initiating a cascade of neuronal responses that culminate in the perception of specific odors.
The inhibition of Olfr732 can be accomplished through various chemical compounds, both directly and indirectly. Direct inhibitors, such as Eugenol and Isoamyl Acetate, bind directly to the receptor, impeding its ability to recognize specific odorants. In contrast, indirect inhibitors, like Ionomycin and Verapamil, exert their influence through modulation of intracellular calcium levels and signaling pathways. These indirect mechanisms can alter Olfr732's responses to odorants, potentially affecting the perception of various scents. Understanding the inhibition of Olfr732 provides valuable insights into the intricate workings of the olfactory system in house mice. It highlights the role of specific chemicals and signaling pathways in modulating sensory perception, enhancing our comprehension of the complex processes involved in odorant recognition and transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol is a direct inhibitor of Olfr732, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of eugenol-like scents. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is an indirect inhibitor that promotes calcium influx, potentially influencing Olfr732's responses to odorants through increased intracellular calcium levels and activation of calcium-dependent signaling pathways. This modulation indirectly impacts sensory perception by altering the intracellular environment. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate is a direct inhibitor that interacts with Olfr732, obstructing the binding of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of banana-like aromas. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is an indirect inhibitor that blocks calcium channels, potentially influencing neuronal responses and modulating Olfr732's function in perceiving odorants. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is an indirect inhibitor that increases intracellular cAMP levels by inhibiting phosphodiesterase 4 (PDE4), which can modulate Olfr732's responses to odorants through alterations in the cAMP-dependent signaling pathway. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin is an indirect inhibitor that activates transient receptor potential vanilloid 1 (TRPV1) channels, influencing neuronal responses and potentially modulating Olfr732's function in perceiving odorants. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an indirect inhibitor that inhibits phosphoinositide 3-kinase (PI3K) and can influence Olfr732's responses to odorants through alterations in the PI3K signaling pathway. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral is a direct inhibitor of Olfr732, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of citrus-like scents. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an indirect inhibitor that promotes calcium ionophore activity, leading to increased intracellular calcium levels and potentially influencing Olfr732's responses to odorants through activation of calcium-dependent signaling pathways. This modulation indirectly affects sensory perception by altering the intracellular environment. | ||||||
Hexyl acetate | 142-92-7 | sc-215149 sc-215149A | 25 ml 500 ml | $32.00 $57.00 | ||
Hexyl Acetate is a direct inhibitor of Olfr732, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of apple-like scents. | ||||||