Olfr730 Inhibitors
Olfr730, a member of the olfactory receptor family 4 subfamily K (OR4K), plays a pivotal role in the olfaction of Mus musculus (house mouse). As with other olfactory receptors, Olfr730 is a G-protein-coupled receptor (GPCR) with a characteristic 7-transmembrane domain structure. Its primary function is to interact with odorant molecules in the nasal cavity, initiating a cascade of neuronal responses that lead to the perception of specific smells. Inhibition of Olfr730 can be achieved through various chemical compounds, both directly and indirectly. Direct inhibitors, such as Citronellal and Cinnamaldehyde, interact directly with the receptor, obstructing the binding of specific odorant molecules. Indirect inhibitors, like SKF 96365 and KN-93, modulate cellular processes and signaling pathways that indirectly affect Olfr730's functionality, potentially altering the perception of various scents.
Understanding the inhibition of Olfr730 provides valuable insights into the complex processes underlying olfaction in mice. It highlights the role of specific chemicals and signaling pathways in modulating sensory perception, shedding light on the intricate mechanisms involved in odorant recognition and transduction. These findings contribute to our understanding of how the olfactory system functions in house mice and may have broader implications for the study of olfaction in other organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal is a direct inhibitor of Olfr730, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of citrus-like scents. | ||||||
SK&F 96365 | 130495-35-1 | sc-201475 sc-201475B sc-201475A sc-201475C | 5 mg 10 mg 25 mg 50 mg | $103.00 $158.00 $397.00 $656.00 | 2 | |
SKF 96365 is an indirect inhibitor that blocks transient receptor potential (TRP) channels, affecting calcium influx. This modulation indirectly influences Olfr730's responses to odorants through alterations in intracellular calcium levels, potentially impacting the perception of various scents. | ||||||
Cinnamic Aldehyde | 104-55-2 | sc-294033 sc-294033A | 100 g 500 g | $104.00 $228.00 | ||
Cinnamaldehyde is a direct inhibitor that interacts with Olfr730, obstructing the binding of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of cinnamaldehyde-like aromas. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $182.00 | 25 | |
KN-93 is an indirect inhibitor that inhibits calmodulin-dependent protein kinase II (CaMKII), influencing calcium-dependent signaling pathways. This indirect modulation can potentially impact Olfr730's responses to odorants, affecting sensory perception through cross-talk with calcium-mediated pathways. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Simvastatin is an indirect inhibitor that disrupts the mevalonate pathway, potentially altering membrane composition and indirectly affecting Olfr730's functionality. Changes in membrane composition can impact receptor function and odorant perception. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an indirect inhibitor that interferes with intracellular calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump. This disruption indirectly influences Olfr730 by altering calcium-dependent signaling pathways, potentially affecting odorant perception. | ||||||
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is an indirect inhibitor that blocks beta-adrenergic receptors, potentially influencing neuronal responses and modulating Olfr730's function in perceiving odorants. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D is an indirect inhibitor that disrupts actin polymerization and cellular structure. This disruption indirectly influences Olfr730 by altering the organization of cellular components involved in receptor function, potentially impacting odorant perception. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
Eucalyptol is a direct inhibitor of Olfr730, capable of binding to the receptor and preventing the recognition of specific odorant molecules. This direct interference disrupts the initiation of neuronal responses responsible for the perception of eucalyptol-like scents. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Quinine is an indirect inhibitor that blocks certain types of ion channels, potentially influencing neuronal excitability and signal transduction pathways. This modulation indirectly impacts Olfr730's responses to odorants, affecting sensory perception through alterations in ion channel activity. | ||||||