Olfr720 Inhibitors
Olfr720 is an olfactory receptor gene responsible for the recognition and transduction of odorant signals in Mus musculus (house mouse). It belongs to the large family of G-protein-coupled receptors (GPCRs) and plays a crucial role in initiating neuronal responses that lead to the perception of smells. Olfactory receptors like Olfr720 share a 7-transmembrane domain structure with neurotransmitter and hormone receptors, enabling them to mediate odorant signal transduction. The olfactory receptor gene family in mice is extensive and has a unique nomenclature for this organism. Inhibition of Olfr720 can be achieved through various mechanisms. Several chemicals have been identified as potential inhibitors. These chemicals target key pathways and processes associated with Olfr720 function. For instance, benzothiadiazole disrupts the cAMP signaling pathway, leading to reduced activation of Olfr720. GSK1802344A inhibits GRK2, prolonging Olfr720 activation and subsequent downregulation. U0126 interferes with the MAPK pathway, indirectly inhibiting Olfr720 by disrupting downstream transcription factors. Verapamil and nifedipine block calcium channels, reducing Olfr720's sensitivity to odorants.
Furthermore, LY341495 acts as an antagonist at metabotropic glutamate receptors, affecting olfactory signal transduction. PD0325901 inhibits the MAPK pathway, while SB202190 targets p38 MAPK, both impacting Olfr720's downstream signaling. 2-APB modulates calcium signaling, affecting olfactory signal amplification. JNJ-1661010 targets GRK2, and AZD6244 inhibits the MAPK pathway, indirectly inhibiting Olfr720. Nicardipine also blocks calcium channels, reducing Olfr720's sensitivity to odorants. These inhibitors offer valuable insights into the mechanisms by which Olfr720 can be modulated, whether directly or indirectly. Understanding these mechanisms is essential for unraveling the complexities of olfactory signal transduction and its regulation in mice. Further research into the precise effects of these chemicals on Olfr720 and their potential applications in olfaction studies is warranted.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 interferes with the MAPK pathway, a downstream signaling pathway of Olfr720. By inhibiting MAPK signaling, it disrupts the activation of transcription factors necessary for Olfr720 expression, indirectly inhibiting the gene. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil inhibits Olfr720 by blocking calcium channels, disrupting intracellular calcium signaling. This reduces Olfr720 sensitivity to odorant molecules, ultimately inhibiting its function. | ||||||
LY 341495 | 201943-63-7 | sc-361244 sc-361244A | 1 mg 10 mg | $89.00 $223.00 | 1 | |
LY341495 acts as an antagonist at metabotropic glutamate receptors, affecting olfactory signal transduction. It leads to reduced activation of Olfr720 and inhibition of its function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine inhibits Olfr720 by blocking calcium channels, disrupting intracellular calcium signaling. This reduces Olfr720 sensitivity to odorant molecules, ultimately inhibiting its function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB202190 inhibits p38 MAPK, a component of the MAPK pathway downstream of Olfr720. This disruption hinders the activation of transcription factors essential for Olfr720 expression, indirectly inhibiting the gene. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB modulates calcium signaling, impacting olfactory signal amplification. It leads to decreased sensitivity of Olfr720 to odorant molecules, ultimately inhibiting its function. | ||||||
Selumetinib | 606143-52-6 | sc-364613 sc-364613A sc-364613B sc-364613C sc-364613D | 5 mg 10 mg 100 mg 500 mg 1 g | $29.00 $82.00 $420.00 $1897.00 $3021.00 | 5 | |
AZD6244 inhibits the MAPK pathway downstream of Olfr720. This disrupts the activation of transcription factors necessary for Olfr720 expression, indirectly inhibiting the gene. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $33.00 $83.00 | 5 | |
Nicardipine inhibits Olfr720 by blocking calcium channels, disrupting intracellular calcium signaling. This reduces Olfr720 sensitivity to odorant molecules, ultimately inhibiting its function. | ||||||