Olfr716 Inhibitors
Olfr716, also known as Or2d36, is an olfactory receptor responsible for initiating neuronal responses to odorant molecules in Mus musculus (house mouse). It belongs to the G-protein-coupled receptor (GPCR) family, characterized by a 7-transmembrane domain structure. These receptors play a pivotal role in recognizing odorants and transducing signals through G protein-mediated pathways. Olfr716 is a member of the largest olfactory receptor gene family in the mouse genome, with a unique nomenclature.
The inhibition of Olfr716 can be achieved through various chemical compounds, both directly and indirectly. Direct inhibitors such as Forskolin, U0126, and Gallein target Olfr716 itself, affecting its ability to recognize odorants. They disrupt key signaling pathways, leading to diminished receptor function and impaired odor perception. Indirect inhibitors like Isoproterenol and Nifedipine modulate secondary pathways like cAMP and calcium signaling. These compounds indirectly hinder Olfr716 activation, reducing its sensitivity to odorants. In conclusion, Olfr716 is a crucial component of the olfactory system in mice, responsible for odor perception. Its inhibition can be achieved through a range of chemical compounds that directly or indirectly disrupt its signaling pathways, ultimately impacting the receptor's function and the perception of smells.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol inhibits Olfr716 indirectly by activating β-adrenergic receptors, which modulate cAMP levels. Reduced cAMP affects Olfr716 activation and odor perception. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a direct Olfr716 inhibitor, activates adenylate cyclase, increasing cAMP levels. Elevated cAMP impairs Olfr716 function, leading to reduced odorant recognition. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine inhibits Olfr716 by blocking calcium channels. Lower intracellular calcium levels due to Nifedipine disrupt Olfr716 sensitivity to odorants. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
Pertussis Toxin indirectly inhibits Olfr716 by inactivating Gαi proteins. This disruption of GPCR signaling impairs the receptor's ability to transduce odorant signals. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 acts as a direct Olfr716 inhibitor by inhibiting MEK1/2, crucial components of the MAPK pathway. This disruption interferes with receptor function and odor perception. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a direct inhibitor of Olfr716 that elevates intracellular cAMP levels. Increased cAMP hinders Olfr716 activation, leading to impaired odorant recognition. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM indirectly inhibits Olfr716 by chelating intracellular calcium ions. Reduced calcium levels affect the receptor's sensitivity to odorants, disrupting olfactory perception. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 is a direct Olfr716 inhibitor that blocks adenylate cyclase activity, reducing cAMP levels. Lowered cAMP impairs Olfr716 activation and odorant perception. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $219.00 $765.00 | 19 | |
Ryanodine indirectly inhibits Olfr716 by blocking ryanodine receptors and reducing calcium release from the endoplasmic reticulum. This affects receptor sensitivity to odorants. | ||||||
Gallein | 2103-64-2 | sc-202631 | 50 mg | $83.00 | 20 | |
Gallein is a direct Olfr716 inhibitor that disrupts G protein-mediated signaling. It impairs receptor activation, leading to a diminished response to odorant molecules. | ||||||