Olfr704 Activators
Olfr704 is an olfactory receptor gene encoding a protein that is part of the G protein-coupled receptor (GPCR) family. These receptors are known for their pivotal role in detecting odorous compounds and are essential for the sense of smell. Olfr704, like other olfactory receptors, is located in the olfactory epithelium and is responsible for the detection of specific odor molecules. The activation of Olfr704, as with other olfactory receptors, involves the binding of odorant molecules to the receptor, which then induces a conformational change in the receptor. This change is crucial as it triggers a series of intracellular events, starting with the activation of a G protein. The activated G protein then stimulates adenylate cyclase, leading to an increase in the intracellular concentration of cyclic AMP (cAMP). The rise in cAMP levels causes the opening of cyclic nucleotide-gated ion channels, leading to an influx of calcium and sodium ions into the cell, and the efflux of potassium ions. This ionic movement creates an electrical signal that is transmitted to the brain, where it is interpreted as a specific smell.
The specificity of olfactory receptor activation, like that of Olfr704, is determined by the structural compatibility between the receptor and the odorant molecule. Different chemical compounds have distinct shapes, sizes, and functional groups, which influence their ability to bind and activate specific receptors. The chemicals listed above are selected based on their potential to fit into the active site of Olfr704, thereby activating the receptor through a lock-and-key mechanism. This direct interaction is critical for the functional activation of Olfr704, leading to the initiation of the olfactory signaling cascade and the subsequent perception of specific odors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ethyl Acetate, HPLC | 141-78-6 | sc-360247 sc-360247A | 1 L 4 L | $122.00 $326.00 | ||
Ethyl acetate, an ester, can potentially activate Olfr704 by engaging in the olfactory signaling pathway. This chemical, due to its volatile nature, may interact directly with the olfactory receptor proteins, like Olfr704, leading to a conformational change that triggers the activation of the receptor. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate, known for its banana-like odor, can activate Olfr704 through direct interaction with the olfactory receptor site. This activation may occur due to the shape and size of the molecule fitting into the receptor binding site, triggering a signal transduction cascade. | ||||||
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Citral, a key component of lemongrass oil, can activate Olfr704 by directly interacting with the receptor site. Its molecular structure allows it to fit into the receptor, causing activation and subsequent signal transduction in the olfactory pathway. | ||||||
1,8-Cineole | 470-82-6 | sc-485261 | 25 ml | $44.00 | 2 | |
1,8-Cineole, a monoterpene, activates Olfr704 through direct binding. Its interaction with the olfactory receptor triggers a cascade of intracellular events, leading to the perception of its characteristic eucalyptus smell. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $84.00 $129.00 | 3 | |
D-Limonene, a cyclic terpene, activates Olfr704 by directly binding to the receptor's ligand-binding domain. This interaction causes a conformational change in the protein, initiating the olfactory signaling cascade. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $47.00 $70.00 | ||
Methyl salicylate, an ester of salicylic acid, activates Olfr704 by fitting into its binding pocket. This interaction leads to the receptor's conformational change, triggering the olfactory signaling pathway. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
α-Pinene, a bicyclic monoterpene, activates Olfr704 through direct binding. Its molecular structure allows for effective interaction with the receptor, leading to activation and signal transduction in olfactory neurons. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $44.00 $124.00 | 1 | |
Vanillin, a phenolic aldehyde, can activate Olfr704 through direct interaction. This compound fits into the receptor's binding site, causing a structural change that leads to the activation of the olfactory signaling pathway. | ||||||
Acetophenone | 98-86-2 | sc-239189 | 5 g | $20.00 | ||
Acetophenone, a ketone with a sweet smell, activates Olfr704 through direct binding. This interaction causes a conformational change in the receptor, leading to the initiation of a signaling pathway specific to olfactory receptors. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $27.00 | ||
Hexanal, an aldehyde with a grassy odor, activates Olfr704 by directly interacting with the receptor. Its molecular structure enables it to effectively bind to the receptor, initiating the olfactory signaling cascade. | ||||||