Olfr589 Activators
Olfr589, also known as the Olfactory Receptor 589, is a protein encoded by the OLFR589 gene. This protein is part of the olfactory receptor family, a group of receptors crucial for the detection of odors and, consequently, the initiation of olfactory signal transduction pathways. As a G protein-coupled receptor (GPCR), Olfr589 plays a significant role in the transduction of olfactory signals, converting chemical signals from odorous compounds into electrical signals in the olfactory neurons. This conversion is essential for the perception of smells. The functionality of Olfr589, like other olfactory receptors, is highly specific, with each receptor typically responding to a limited range of odorant molecules with specific structural characteristics.
The activation mechanisms of Olfr589 involve the binding of specific odorant molecules, which leads to a conformational change in the receptor. This conformational change is crucial as it triggers a cascade of intracellular events. Upon activation, Olfr589 interacts with a G protein (Golf in olfactory neurons), leading to the exchange of GDP for GTP on the alpha subunit of the G protein. This exchange results in the activation of adenylate cyclase, which increases the concentration of cyclic AMP (cAMP). The rise in cAMP levels causes the opening of cyclic nucleotide-gated ion channels, leading to an influx of calcium and sodium ions into the cell. This influx generates an action potential that transmits the signal to the brain, where it is interpreted as a distinct smell. Therefore, the activation of Olfr589 is not just the binding of an odorant but a complex process involving multiple steps in signal transduction.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $105.00 $221.00 | ||
Isopentyl acetate, known for its banana-like odor, activates Olfr589 through direct interaction with its odorant binding site. This binding causes a change in the receptor's structure, triggering the activation of intracellular signal transduction mechanisms associated with olfactory G-protein coupled receptors. | ||||||
4-Methoxybenzaldehyde | 123-11-5 | sc-238884 sc-238884A sc-238884B sc-238884C | 5 g 100 g 250 g 1 kg | $29.00 $41.00 $71.00 $122.00 | ||
4-Methoxybenzaldehyde engages with Olfr589 by docking at its odorant-binding site, initiating receptor activation. The activation of Olfr589 by anisaldehyde stimulates the downstream G-protein coupled pathways, which are integral to the olfactory signal transduction process. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $31.00 $61.00 $214.00 | 2 | |
Eugenol interacts with Olfr589 at its specific binding pocket, causing activation of the receptor. This activation leads to the initiation of G-protein signaling cascades, which are essential for the transduction of olfactory signals. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal binds to Olfr589, inducing a structural change that activates the receptor. This activation facilitates the propagation of signal transduction pathways linked to olfactory receptor activation, thereby contributing to the sensory perception of smell. | ||||||
Ethyl butyrate | 105-54-4 | sc-214986 sc-214986A | 1 kg 4 kg | $100.00 $210.00 | ||
Ethyl butyrate activates Olfr589 through direct binding, which alters the receptor conformation and triggers the activation of downstream G-protein coupled signaling pathways. These pathways are crucial for olfactory signal transmission and perception. | ||||||
Hexanal | 66-25-1 | sc-252885 | 2 ml | $26.00 | ||
Hexanal activates Olfr589 by directly interacting with its ligand-binding domain. This interaction leads to a conformational shift in the receptor, which in turn activates the associated G-protein signaling mechanisms essential for olfactory processing. | ||||||
D-Limonene | 5989-27-5 | sc-205283 sc-205283A | 100 ml 500 ml | $82.00 $126.00 | 3 | |
D-Limonene binds specifically to Olfr589, resulting in its activation. This binding and subsequent activation trigger a series of G-protein mediated signaling events that are fundamental to the function of olfactory receptors in scent detection. | ||||||
Methyl Salicylate | 119-36-8 | sc-204802 sc-204802A | 250 ml 500 ml | $46.00 $69.00 | ||
Methyl salicylate activates Olfr589 by directly binding to its ligand-specific site. This interaction initiates a conformational change in the receptor, leading to the activation of G-protein mediated signaling pathways involved in olfactory signal transduction. | ||||||
Vanillin | 121-33-5 | sc-251423 sc-251423A | 100 g 500 g | $43.00 $122.00 | 1 | |
Vanillin, by binding to Olfr589, activates the receptor. This activation is pivotal for the initiation of intracellular signaling cascades mediated by G-proteins, which are integral to the olfactory sensory response. | ||||||
Geraniol | 106-24-1 | sc-235242 sc-235242A | 25 g 100 g | $44.00 $117.00 | ||
Geraniol interacts with Olfr589 at its odorant-binding site, activating the receptor. This activation is essential for the propagation of olfactory signaling pathways, facilitating the perception of specific scents. | ||||||