Olfr543 Inhibitors
Olfr543, a member of the olfactory receptor family, plays a pivotal role in olfactory signal transduction, contributing significantly to the detection and discrimination of specific odorants. Functionally, Olfr543 acts as a molecular sensor that initiates intricate cascades of events upon binding to its cognate ligands, thereby enabling organisms to interpret and respond to a diverse array of olfactory stimuli.
The inhibition of Olfr543 involves a sophisticated interplay with various signaling pathways, particularly those associated with vascular endothelial growth factor receptors (VEGFR), Janus kinase/signal transducer and activator of transcription (JAK/STAT), and phosphoinositide 3-kinase (PI3-kinase). Inhibitors such as Sorafenib, Axitinib, and Ruxolitinib directly target these pathways, disrupting Olfr543 activation by inhibiting kinase activities and hindering downstream cascades crucial for Olfr543 function. Additionally, compounds like BKM120 and Dasatinib modulate the PI3-kinase and SRC family kinase pathways, respectively, altering phosphorylation events crucial for Olfr543 function and downstream signaling. The diverse mechanisms employed by these inhibitors underscore the intricacies of Olfr543 inhibition, providing valuable insights into potential strategies for controlling olfactory signal transduction at the molecular level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Multikinase inhibitor targeting RAF, VEGFR, and PDGFR pathways associated with Olfr543. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr543 function. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
JAK1/2 inhibitor affecting the JAK/STAT pathway linked to Olfr543. Modulates intracellular signaling by inhibiting JAK1/2 kinase activity, hindering downstream cascades crucial for Olfr543 function. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AKT kinase inhibitor selectively blocking a pathway associated with Olfr543 activation. Modulates cellular processes by impeding key intermediates, resulting in the suppression of Olfr543 activity. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $193.00 $510.00 $1072.00 | 4 | |
Multikinase inhibitor targeting VEGFR, PDGFR, and FLT3 pathways associated with Olfr543. Impedes kinase activities, disrupting phosphorylation events crucial for Olfr543 function and downstream signaling. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $173.00 $230.00 $275.00 $332.00 | 9 | |
PI3-kinase inhibitor that disrupts the PI3-kinase pathway linked to Olfr543. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr543 function. | ||||||
Trametinib | 871700-17-3 | sc-364639 sc-364639A sc-364639B | 5 mg 10 mg 1 g | $112.00 $163.00 $928.00 | 19 | |
Selectively inhibits the MEK pathway, leading to a cascade of events that suppress Olfr543 function. Alters the phosphorylation status of critical proteins to hinder downstream signaling. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Multikinase inhibitor targeting SRC family kinases associated with Olfr543 activation. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr543 function. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Inhibitor targeting ABL, PDGFR, and KIT pathways associated with Olfr543. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr543 function. | ||||||
Doramapimod | 285983-48-4 | sc-300502 sc-300502A sc-300502B | 25 mg 50 mg 100 mg | $149.00 $281.00 $459.00 | 2 | |
Selective p38 MAP kinase inhibitor disrupting the MAPK pathway associated with Olfr543 activation. Interferes with phosphorylation events crucial for Olfr543 function, hindering downstream signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3-kinase inhibitor blocking the PI3-kinase pathway linked to Olfr543. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr543 function. | ||||||