Date published: 2025-10-26

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Olfr543 Inhibitors

Olfr543, a member of the olfactory receptor family, plays a pivotal role in olfactory signal transduction, contributing significantly to the detection and discrimination of specific odorants. Functionally, Olfr543 acts as a molecular sensor that initiates intricate cascades of events upon binding to its cognate ligands, thereby enabling organisms to interpret and respond to a diverse array of olfactory stimuli.

The inhibition of Olfr543 involves a sophisticated interplay with various signaling pathways, particularly those associated with vascular endothelial growth factor receptors (VEGFR), Janus kinase/signal transducer and activator of transcription (JAK/STAT), and phosphoinositide 3-kinase (PI3-kinase). Inhibitors such as Sorafenib, Axitinib, and Ruxolitinib directly target these pathways, disrupting Olfr543 activation by inhibiting kinase activities and hindering downstream cascades crucial for Olfr543 function. Additionally, compounds like BKM120 and Dasatinib modulate the PI3-kinase and SRC family kinase pathways, respectively, altering phosphorylation events crucial for Olfr543 function and downstream signaling. The diverse mechanisms employed by these inhibitors underscore the intricacies of Olfr543 inhibition, providing valuable insights into potential strategies for controlling olfactory signal transduction at the molecular level.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Multikinase inhibitor targeting RAF, VEGFR, and PDGFR pathways associated with Olfr543. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr543 function.

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$246.00
$490.00
$536.00
16
(1)

JAK1/2 inhibitor affecting the JAK/STAT pathway linked to Olfr543. Modulates intracellular signaling by inhibiting JAK1/2 kinase activity, hindering downstream cascades crucial for Olfr543 function.

AZD5363

1143532-39-1sc-503190
5 mg
$309.00
(0)

AKT kinase inhibitor selectively blocking a pathway associated with Olfr543 activation. Modulates cellular processes by impeding key intermediates, resulting in the suppression of Olfr543 activity.

Sunitinib Malate

341031-54-7sc-220177
sc-220177A
sc-220177B
10 mg
100 mg
3 g
$193.00
$510.00
$1072.00
4
(1)

Multikinase inhibitor targeting VEGFR, PDGFR, and FLT3 pathways associated with Olfr543. Impedes kinase activities, disrupting phosphorylation events crucial for Olfr543 function and downstream signaling.

BKM120

944396-07-0sc-364437
sc-364437A
sc-364437B
sc-364437C
5 mg
10 mg
25 mg
50 mg
$173.00
$230.00
$275.00
$332.00
9
(0)

PI3-kinase inhibitor that disrupts the PI3-kinase pathway linked to Olfr543. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr543 function.

Trametinib

871700-17-3sc-364639
sc-364639A
sc-364639B
5 mg
10 mg
1 g
$112.00
$163.00
$928.00
19
(1)

Selectively inhibits the MEK pathway, leading to a cascade of events that suppress Olfr543 function. Alters the phosphorylation status of critical proteins to hinder downstream signaling.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Multikinase inhibitor targeting SRC family kinases associated with Olfr543 activation. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr543 function.

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$25.00
$117.00
$209.00
27
(1)

Inhibitor targeting ABL, PDGFR, and KIT pathways associated with Olfr543. Modulates intracellular signaling by impeding kinase activities, hindering downstream cascades crucial for Olfr543 function.

Doramapimod

285983-48-4sc-300502
sc-300502A
sc-300502B
25 mg
50 mg
100 mg
$149.00
$281.00
$459.00
2
(1)

Selective p38 MAP kinase inhibitor disrupting the MAPK pathway associated with Olfr543 activation. Interferes with phosphorylation events crucial for Olfr543 function, hindering downstream signaling.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

PI3-kinase inhibitor blocking the PI3-kinase pathway linked to Olfr543. Alters intracellular signaling by inhibiting PI3-kinase activity, hindering downstream cascades crucial for Olfr543 function.