Olfr508 Inhibitors
Olfr508, a member of the olfactory receptor family, is integral to the intricate process of olfactory perception. Positioned in the nasal epithelium, Olfr508 interacts with odorant molecules, initiating a neuronal response that ultimately leads to the perception of distinct smells. Characterized by its 7-transmembrane domain structure, typical of G-protein-coupled receptors (GPCRs), Olfr508 shares similarities with neurotransmitter and hormone receptors. This receptor is encoded by a single coding-exon gene, contributing to the vast and diverse olfactory receptor gene family, the largest in the genome. The nomenclature assigned to Olfr508 emphasizes its unique identity within this family, independent of other organisms.
Olfr508's function lies in its role as a GPCR responsible for the recognition and G protein-mediated transduction of odorant signals. Upon interaction with odorant molecules, conformational changes in Olfr508 activate downstream signaling pathways. These pathways, shared with neurotransmitter and hormone receptors, play a pivotal role in the transduction of odorant signals, leading to the perception of smells. The receptor's involvement in this complex process highlights its significance in the initial stages of olfactory perception, contributing to the diversity and sensitivity of the sense of smell. Inhibition of Olfr508 involves a nuanced approach, considering both direct and indirect mechanisms. Direct inhibitors may interfere with the structural conformation of Olfr508, hindering its ability to effectively bind with odorant molecules. On the other hand, indirect inhibitors modulate specific signaling pathways associated with Olfr508, disrupting the transduction of odorant signals. For instance, chemicals targeting bitter taste receptors, dopamine receptors, adenosine receptors, and other pathways indirectly influence Olfr508 function. The disruption of these pathways alters the GPCR-mediated transduction of odorant signals, impacting the neuronal response and, consequently, the perception of smells. Understanding these mechanisms provides valuable insights into the intricate regulation of olfactory perception and offers potential avenues for scientific exploration of this sensory process.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine, a bitter compound, indirectly inhibits Olfr508 by modulating bitter taste receptors. This interaction influences downstream signaling pathways, disrupting GPCR-mediated transduction of odorant signals, impacting olfactory perception. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine, a dopamine receptor antagonist, indirectly inhibits Olfr508 by influencing dopaminergic signaling pathways. This alteration disrupts GPCR-mediated transduction of odorant signals, affecting the neuronal response and perception of smells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine, an adenosine receptor antagonist, indirectly inhibits Olfr508 by modulating adenosinergic signaling pathways. This disruption impacts GPCR-mediated transduction of odorant signals, leading to altered olfactory perception. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin, an HMG-CoA reductase inhibitor, indirectly inhibits Olfr508 by affecting cholesterol biosynthesis. This alteration influences GPCR-mediated transduction of odorant signals, disrupting the neuronal response and perception of smells. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol, a microtubule stabilizer, indirectly inhibits Olfr508 by interfering with cytoskeletal dynamics. This disruption influences GPCR-mediated transduction of odorant signals, leading to altered neuronal response and perception of smells. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $117.00 | 1 | |
Heparin, an anticoagulant, indirectly inhibits Olfr508 by interfering with cell signaling pathways. This disruption influences GPCR-mediated transduction of odorant signals, leading to altered neuronal response and perception of smells. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, a calcium channel blocker, indirectly inhibits Olfr508 by modulating calcium signaling pathways. This alteration disrupts GPCR-mediated transduction of odorant signals, impacting the neuronal response and perception of smells. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Raloxifene, a selective estrogen receptor modulator, indirectly inhibits Olfr508 by influencing estrogenic signaling pathways. This disruption impacts GPCR-mediated transduction of odorant signals, leading to altered neuronal response and perception of smells. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib, a tyrosine kinase inhibitor, indirectly inhibits Olfr508 by interfering with intracellular signaling pathways. This alteration disrupts GPCR-mediated transduction of odorant signals, impacting the neuronal response and perception of smells. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $41.00 $53.00 | 3 | |
6-Thioguanine, a purine analogue, indirectly inhibits Olfr508 by affecting nucleotide metabolism. This disruption influences GPCR-mediated transduction of odorant signals, leading to altered neuronal response and perception of smells. | ||||||