Olfr402 Inhibitors
The Olfr402 olfactory receptor, a prominent member of the G-protein-coupled receptor (GPCR) family, orchestrates the intricate process of odor perception by interacting with odorant molecules. This receptor, like others in the olfactory gene family, exhibits a 7-transmembrane domain structure and plays a pivotal role in G protein-mediated transduction of odorant signals. As the largest gene family in the genome, the olfactory receptors, including Olfr402, contribute significantly to the diversity and precision of smell perception.
Inhibiting Olfr402 involves a sophisticated approach employing both direct and indirect mechanisms. Direct inhibition entails the disruption of the receptor's function by binding to it and interfering with the 7-transmembrane domain structure. This interference hampers the receptor's ability to transduce odorant signals effectively through G protein-mediated pathways, resulting in the inhibition of olfactory perception. On the other hand, indirect inhibition targets associated signaling pathways, such as cAMP, TRP channels, GABAergic transmission, and cyclic nucleotide signaling. These indirect inhibitors modulate these pathways, leading to altered G protein-mediated transduction of odorant signals and providing an additional layer of inhibition for Olfr402. The diverse array of inhibitors reflects a nuanced strategy to disrupt Olfr402's role in odor recognition, offering avenues for experimental exploration and validation of these inhibition mechanisms. Experimental validation is crucial to confirm the efficacy of these inhibitors in practice and further unravel the intricacies of olfactory signal transduction mediated by Olfr402.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(+)-Carvone | 2244-16-8 | sc-239480 sc-239480A | 5 ml 25 ml | $33.00 $84.00 | 2 | |
Carvone serves as a direct inhibitor by disrupting the 7-transmembrane domain structure of Olfr402. Its interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
(±)-Citronellal | 106-23-0 | sc-234400 | 100 ml | $51.00 | ||
Citronellal functions as a direct inhibitor by binding to Olfr402 and disrupting the 7-transmembrane domain structure. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
2-Phenylethanol | 60-12-8 | sc-238198 | 250 ml | $69.00 | ||
2-Phenylethanol serves as an indirect inhibitor by influencing the cyclic nucleotide signaling pathway linked to Olfr402. Its modulation of this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Octanal | 124-13-0 | sc-250612 sc-250612A | 25 ml 100 ml | $26.00 $34.00 | ||
Octanal acts as a direct inhibitor by binding to Olfr402 and disrupting the 7-transmembrane domain structure. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
α-Pinene | 80-56-8 | sc-233784 sc-233784A | 5 ml 250 ml | $52.00 $115.00 | 2 | |
Alpha-pinene serves as an indirect inhibitor by modulating the cAMP signaling pathway associated with Olfr402. Its influence on this pathway leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Eugenol | 97-53-0 | sc-203043 sc-203043A sc-203043B | 1 g 100 g 500 g | $32.00 $62.00 $218.00 | 2 | |
Eugenol acts as a direct inhibitor by binding to Olfr402 and disrupting the 7-transmembrane domain structure. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||
Picrotoxin | 124-87-8 | sc-202765 sc-202765A sc-202765B | 1 g 5 g 25 g | $67.00 $286.00 $1326.00 | 11 | |
Picrotoxin serves as an indirect inhibitor by influencing the GABAergic signaling pathway associated with Olfr402. Its modulation of GABAergic transmission leads to altered G protein-mediated transduction of odorant signals, indirectly inhibiting the olfactory receptor's function. | ||||||
Isopentyl acetate | 123-92-2 | sc-250190 sc-250190A | 100 ml 500 ml | $107.00 $225.00 | ||
Isopentyl acetate acts as a direct inhibitor by binding to Olfr402 and disrupting the 7-transmembrane domain structure. This interference hinders the receptor's ability to transduce odorant signals through G protein-mediated pathways, resulting in the inhibition of olfactory perception. | ||||||