Olfr38 Inhibitors
Or2f1b, belonging to the olfactory receptor family 2 subfamily F in Mus musculus (house mouse), intricately orchestrates the initial stages of olfactory perception. As a member of the large family of G-protein-coupled receptors (GPCRs), Or2f1b's function is paramount in the complex process of detecting and transducing odorant signals within the nasal environment. The olfactory receptor gene family, being the largest in the genome, underscores the significance of Or2f1b and its counterparts in mediating the perception of smells. With a 7-transmembrane domain structure shared with neurotransmitter and hormone receptors, Or2f1b exhibits a fundamental design that enables its participation in the recognition and G protein-mediated transduction of odorant signals, contributing to the diverse sensory experiences facilitated by olfaction.
The general mechanisms of inhibiting Or2f1b involve a sophisticated interplay of chemical modulators that impact specific cellular pathways crucial for GPCR-mediated transduction of odorant signals. These inhibitors operate through various means, such as blocking sodium channels, modulating potassium channels, inhibiting PI3-kinase, disrupting the prostaglandin pathway, and targeting receptors like dopamine and TRPV1. These diverse mechanisms of inhibition showcase the intricate regulatory network that governs the function of Or2f1b. By disrupting these signaling pathways, the inhibitors impede the receptor's ability to initiate neuronal responses in the presence of odorant molecules, leading to a hindrance in the normal transduction of odorant signals. This multifaceted understanding of Or2f1b's function and its inhibition not only provides insights into the molecular basis of olfactory perception in mice but also highlights the complex interplay between receptor function and regulatory pathways within cellular environments.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a direct inhibitor of Or2f1b, blocking sodium channels and hindering GPCR-mediated transduction. This interference impairs the initiation of neuronal responses to odorant molecules in the nose by disrupting the transduction of odorant signals. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin directly inhibits Or2f1b by targeting PI3-kinase and disrupting downstream signaling pathways. This interference inhibits GPCR-mediated transduction of odorant signals, impeding the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Flupirtine Maleate | 75507-68-5 | sc-218512 | 10 mg | $101.00 | 1 | |
Flupirtine acts as a direct inhibitor of Or2f1b by modulating KCNQ potassium channels. This interference disrupts GPCR-mediated transduction of odorant signals, impairing the initiation of neuronal responses to odorant molecules in the nose. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $52.00 $86.00 | 6 | |
Ibuprofen is a direct inhibitor of Or2f1b, inhibiting cyclooxygenase and disrupting the prostaglandin pathway. This interference impairs GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose. | ||||||
SCH 23390 | 125941-87-9 | sc-200408 sc-200408A | 5 mg 25 mg | $175.00 $719.00 | 2 | |
SCH-23390 indirectly inhibits Or2f1b by blocking dopamine receptors. This modulation influences intracellular cAMP levels, disrupting the cAMP signaling pathway and impeding neuronal responses to odorant molecules in the nose. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a direct inhibitor of Or2f1b, targeting the endoplasmic reticulum Ca2+ pump. This interference disrupts intracellular calcium homeostasis, hindering GPCR-mediated transduction of odorant signals and impeding neuronal responses to odorant molecules in the nose. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine indirectly inhibits Or2f1b by blocking TRPV1 receptors. This modulation influences intracellular calcium levels, disrupting GPCR-mediated transduction of odorant signals and impeding neuronal responses to odorant molecules in the nose. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM indirectly inhibits Or2f1b by chelating intracellular calcium. This modulation influences GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose through modulation of calcium-dependent processes. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 directly interferes with Or2f1b by inhibiting MEK and disrupting the MAPK pathway. This interference impairs GPCR-mediated transduction of odorant signals, hindering the initiation of neuronal responses to odorant molecules in the nose through modulation of the MAPK pathway. | ||||||