Olfr340 Inhibitors
Inhibitors of the olfactory receptor Olfr340 have been developed to address its specific signaling pathways and molecular interactions. These chemical compounds exploit various aspects of cellular function to decrease the activity of Olfr340. For instance, some inhibitors disrupt the endocytic pathway and vesicular pH, thereby preventing the internalization and degradation of Olfr340, which is vital for its turnover and function. Others target the protein biosynthesis machinery, hindering the translation and subsequent synthesis of Olfr340. Additionally, compounds that interfere with cellular ion gradients or the phosphorylation events of downstream signaling molecules can lead to a reduction in Olfr340's signal transduction capability.
Furthermore, the integrity of membrane microdomains like lipid rafts, which are crucial for the proper localization and function of many receptors, including Olfr340, can be disrupted by inhibitors that bind to cholesterol or extract it from the plasma membrane. Certain inhibitors also act by clustering membrane proteins, thus immobilizing them and reducing their functional mobility. The strategic inhibition of organic anion transporters or the blocking of neuronal action potential propagation serve as additional indirect methods to decrease Olfr340's activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
By inhibiting eukaryotic protein biosynthesis, specifically the translocation step in protein synthesis, this compound indirectly affects the turnover of membrane proteins such as Olfr340 by preventing the synthesis of nascent proteins. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Increases the pH of acidic vesicles, such as endosomes and lysosomes, leading to impaired degradation of membrane proteins including Olfr340, thus indirectly inhibiting its turnover and function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
As a GTPase inhibitor of dynamin, this chemical prevents the pinching off of clathrin-coated vesicles, which is necessary for endocytosis. This action would indirectly inhibit the internalization and recycling of membrane proteins like Olfr340. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
This inhibitor of the V-ATPase proton pump disrupts endosomal acidification, which indirectly affects the trafficking and degradation of membrane proteins such as Olfr340 by inhibiting their delivery to lysosomes. | ||||||
2-Hydroxypropyl-β-cyclodextrin | 128446-35-5 | sc-203461 sc-203461B sc-203461C sc-203461A | 1 g 100 g 500 g 5 g | $52.00 $620.00 $1950.00 $130.00 | 8 | |
By extracting cholesterol from plasma membranes, this chemical disrupts lipid rafts. This could indirectly inhibit the correct localization and function of membrane proteins like Olfr340 which may be associated with these rafts. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase inhibitor that by inhibiting autophosphorylation of receptor tyrosine kinases, could indirectly inhibit the downstream signaling pathways involved in the functional regulation of proteins like Olfr340. | ||||||
Ouabain-d3 (Major) | sc-478417 | 1 mg | $506.00 | |||
Inhibits the Na⁺/K⁺-ATPase pump, leading to disruptions in ionic gradients across the plasma membrane, which could indirectly inhibit signal transduction processes for membrane proteins such as Olfr340. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $117.00 $357.00 $928.00 | 17 | |
This lectin binds to mannose residues on glycoproteins and could potentially cluster and immobilize proteins like Olfr340 on the cell surface, indirectly inhibiting their mobility and function. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Inhibits organic anion transporters and may indirectly inhibit the removal of signaling molecules from the extracellular space, leading to sustained activation and possible desensitization of membrane proteins like Olfr340. | ||||||