Odf2L Inhibitors
Outer dense fiber protein 2-like (Odf2L) inhibitors encompass a range of chemical compounds that lead to the inhibition of Odf2L through their actions on microtubule dynamics, with which Odf2L is intimately associated. Microtubule-disrupting agents like nocodazole, colchicine, vinblastine, and vincristine inhibit tubulin polymerization or promote microtubule depolymerization, thereby destabilizing the microtubule structures that Odf2L is known to associate with and maintain. Similarly, podophyllotoxin and dolastatin 10 act by inhibiting microtubule assembly and inducing tubulin depolymerization, respectively, which compromises the microtubule network and indirectly inhibits the structural and organizational roles of Odf2L. Conversely, compounds such as Taxol and peloruside A, through microtubule hyperstabilization, also indirectly inhibit Odf2Lby preventing the dynamic rearrangement of microtubules necessary for its function. Such inhibitors highlight the critical nature of microtubule dynamics in modulating Odf2L activity.
Eribulin, griseofulvin, and 2-methoxyestradiol, which target microtubule growth or function, further exemplify the indirect inhibition of Odf2L by disrupting the integrity of the microtubule network integral to Odf2L's role. Eribulin inhibits the growth phase of microtubule dynamics, while griseofulvin binds to tubulin to disrupt microtubule function, each leading to diminished Odf2L-dependent organization within the cytoskeleton. In a similar fashion, 2-methoxyestradiol impairs microtubule polymerization, weakening the cytoskeletal framework that Odf2L helps to establish. Lastly, harmine interferes with microtubule dynamics by inhibiting tubulin polymerization, culminating in the functional inhibition of Odf2L. Through these varied yet interconnected mechanisms, each of these Odf2L inhibitors contributes to the attenuation of Odf2L activity by targeting the microtubule structures and dynamics essential for its biological function, thereby providing a composite picture of the multifaceted regulation of Odf2L.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization into microtubules, which disrupts mitotic spindle formation. Since Outer dense fiber protein 2-like (Odf2L) is associated with the cytoskeleton and microtubules, colchicine's action indirectly leads to the functional inhibition of Odf2L by destabilizing the microtubule structures it associates with. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a synthetic compound that inhibits microtubule polymerization. By disassembling microtubules, nocodazole indirectly inhibits Odf2L function, given Odf2L's role in the structural integrity and organization of microtubules. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and prevents their depolymerization. This hyperstabilization indirectly inhibits Odf2L, as Odf2L requires dynamic microtubules for its function in the organization of the cytoskeleton. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule assembly. This action disrupts microtubule dynamics, indirectly inhibiting Odf2L's function in maintaining the structural framework of microtubules. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin is an inhibitor of tubulin polymerization and microtubule assembly. The disruption of microtubule dynamics by podophyllotoxin indirectly leads to the inhibition of Odf2L function, considering Odf2L's role in microtubule-related processes. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubule dynamics, which indirectly inhibits Odf2L by impairing the microtubule network that Odf2L is involved in organizing and stabilizing. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, which indirectly inhibits Odf2L's role in microtubule organization and the cytoskeletal framework. | ||||||
Dolastatin 10 | 110417-88-4 | sc-507413 | 5 mg | $980.00 | ||
Dolastatin 10 is a potent inhibitor of microtubule assembly and induces tubulin depolymerization, indirectly inhibiting Odf2L by disrupting microtubule integrity, with which Odf2L is closely associated. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol inhibits microtubule polymerization and disrupts microtubule networks, indirectly leading to the inhibition of Odf2L, which is dependent on the microtubule cytoskeleton for its function. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $52.00 $102.00 $124.00 $540.00 $1438.00 $2560.00 $11230.00 | 2 | |
Harmine is known to disrupt microtubule dynamics by inhibiting the polymerization of tubulin. This action leads to an indirect inhibition of Odf2L, which plays a role in the structural organization of the microtubule cytoskeleton. | ||||||