OBFC2B Inhibitors
Chemical inhibitors of OBFC2B can exert their inhibitory effects through interference with DNA replication and repair processes, in which OBFC2B is a key player. Aphidicolin acts by targeting DNA polymerase, a critical enzyme for DNA replication. As OBFC2B is implicated in stabilizing replication forks, the inhibition of DNA polymerase can undermine the protein's functional role by impeding the replication process it is meant to safeguard. Similarly, Etoposide and Mitoxantrone, by stabilizing the DNA topoisomerase II complex in an aberrant state and intercalating into DNA respectively, prevent the ligation of DNA strands and promote DNA breaks. This accumulation of DNA damage indirectly restricts OBFC2B's function in DNA repair as the protein is overwhelmed by the increased demand for repair mechanisms. Camptothecin and Topotecan, both topoisomerase I inhibitors, lead to DNA damage during replication and transcription, further burdening the DNA repair machinery involving OBFC2B.
Actinomycin D, by binding to DNA, prevents RNA synthesis, thereby indirectly inhibiting the nucleoprotein complex formation essential for OBFC2B's role in DNA stability. Amsacrine, Daunorubicin, and Doxorubicin, all function as topoisomerase II inhibitors, which disrupt DNA synthesis and function, leading to an indirect inhibition of OBFC2B's DNA repair and replication activities. Bleomycin introduces DNA strand breaks by generating free radicals, adding to the pool of DNA damage that OBFC2B must process, thereby hindering its function. Hydroxyurea undermines OBFC2B's activity by depleting the pool of deoxyribonucleotides necessary for DNA synthesis, indirectly affecting the protein's involvement in DNA replication. Teniposide, like Etoposide, impedes topoisomerase II, exacerbating DNA damage and thus indirectly inhibiting the DNA repair and stabilization functions of OBFC2B, by causing an overload of DNA lesions that OBFC2B is unable to efficiently repair.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin inhibits DNA polymerase, which is essential for DNA replication. By inhibiting DNA replication, it indirectly inhibits OBFC2B's role in DNA replication and repair pathways since OBFC2B is involved in stabilizing replication forks. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide stabilizes the DNA topoisomerase II complex after it breaks the DNA strand for replication, preventing the ligation of the DNA strands. This leads to inhibition of DNA replication and indirectly inhibits OBFC2B function which is involved in DNA repair and replication. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, leading to DNA damage during replication. OBFC2B, which plays a role in DNA repair, is indirectly inhibited as the increased DNA damage overwhelms the repair mechanisms. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and prevents RNA synthesis by RNA polymerase. This inhibits transcription and indirectly inhibits OBFC2B by limiting the nucleoprotein complex formation it requires for proper function in DNA stabilization. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
Mitoxantrone intercalates into DNA and inhibits topoisomerase II, leading to DNA damage and apoptosis. This indirectly inhibits OBFC2B's function in DNA repair as the damage accrues. | ||||||
Amsacrine hydrochloride | 54301-15-4 | sc-214540 | 10 mg | $232.00 | ||
Amsacrine is a topoisomerase II inhibitor that disrupts DNA synthesis and function, indirectly inhibiting OBFC2B's DNA repair and replication activities. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Bleomycin causes DNA strand breaks by free radical formation, which indirectly inhibits OBFC2B's role in DNA repair since it is involved in the processing of stalled replication forks. | ||||||
Daunorubicin hydrochloride | 23541-50-6 | sc-200921 sc-200921A sc-200921B sc-200921C | 10 mg 50 mg 250 mg 1 g | $103.00 $429.00 $821.00 $1538.00 | 4 | |
Daunorubicin intercalates into DNA and inhibits the progression of topoisomerase II, leading to DNA breaks. OBFC2B's function is indirectly inhibited as it is unable to adequately address the increased DNA damage. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts topoisomerase II's DNA-relaxing function, causing DNA damage and indirectly inhibiting OBFC2B's DNA repair function. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, decreasing the pool of deoxyribonucleotides available for DNA synthesis, indirectly inhibiting OBFC2B activity in DNA replication. | ||||||