OBFC1 Activators
OBFC1 Activators are a diverse array of chemical compounds that indirectly enhance the functional activity of OBFC1 by modulating different cellular pathways and processes. Forskolin and Caffeine exert their effects by increasing intracellular cAMP levels, with Forskolin activating adenylate cyclase directly and Caffeine inhibiting phosphodiesterases. The elevated cAMP levels subsequently activate PKA, which can then phosphorylate proteins and substrates that interact with OBFC1, stabilizing it and promoting its role in genome maintenance. Similarly, Resveratrol activates SIRT1, which may deacetylate and prepare a conducive cellular environment for OBFC1's involvement in DNA repair, while Curcumin activates transcription factors that upregulate genes within the DNA damage response, potentially creating a demand for OBFC1's function. Zinc sulfate enhances DNA repair protein activity and could improve OBFC1's structural integrity, while Nicotinamide riboside elevates NAD+ levels, indirectly supporting OBFC1 through enhanced sirtuin-mediated DNA repair regulation.
In addition to these mechanisms, Sulforaphane activates Nrf2, bolstering the cell's antioxidant defenses which could indirectly preserve OBFC1 function by minimizing oxidative DNA damage. Metformin, through AMPK activation, potentially upregulates DNA repair and genome integrity pathways that could include OBFC1's activities, while Quercetin's antioxidant properties could create a protective environment for OBFC1-mediated DNA repair. Oleuropein and Epigallocatechin gallate (EGCG) both contribute to reducing oxidative stress, which may support OBFC1's role in DNA damage recognition and repair. Lastly, Piperlongumine, by modulating ROS levels, may activate DNA repair pathways where OBFC1 is crucial, thus indirectly enhancing its activity. Collectively, these OBFC1 Activators work through various biochemical mechanisms, ultimately contributing to the enhancement of OBFC1's role in maintaining genomic stability without directly increasing its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a labdane diterpenoid and activates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate specific substrates that may interact with OBFC1 to promote its stabilization and function in the maintenance of genome stability. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is a methylxanthine that inhibits phosphodiesterases, thereby preventing the degradation of cAMP and increasing its concentration in the cell. This rise in cAMP can enhance the activity of PKA, which may indirectly enhance the functional activity of OBFC1 by phosphorylation mechanisms that support its role in nucleic acid processing. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound that can activate sirtuin 1 (SIRT1), an NAD+-dependent deacetylase. Activation of SIRT1 has been implicated in the regulation of various cellular processes including DNA repair. SIRT1 activation may deacetylate certain substrates to create a favorable environment for the activity of OBFC1 in DNA damage response. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a biologically active polyphenolic compound found in turmeric, has been shown to activate various transcription factors that may enhance the expression of genes involved in the DNA damage response, providing a context in which OBFC1 function could be indirectly enhanced due to increased demand for DNA repair and replication stress response proteins. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc is a trace element that serves as a cofactor for numerous enzymes and proteins. Zinc ions can modulate the activity of DNA repair proteins and may enhance the proper folding and function of OBFC1 as it participates in the complex network of DNA damage sensing and repair machinery. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside is a precursor of NAD+ and can increase intracellular NAD+ levels, thereby potentially enhancing sirtuin activity, including SIRT1. This increase in sirtuin activity can indirectly support the functional role of OBFC1 through improved regulation of DNA repair processes and maintenance of genomic stability. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane is an isothiocyanate from cruciferous vegetables that can activate Nrf2, a transcription factor that regulates the expression of antioxidant proteins that protect against oxidative damage. By promoting the cellular antioxidant capacity, sulforaphane may indirectly enhance the function of OBFC1 by reducing oxidative stress on DNA and the associated repair machinery. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin is a biguanide drug that activates AMP-activated protein kinase (AMPK). AMPK activation can lead to changes in cellular energy balance and may enhance the DNA damage response. This could indirectly support the functional activity of OBFC1 by upregulating cellular mechanisms involved in maintaining genome integrity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been shown to have antioxidant properties and may modulate kinase activity. Its role in cellular protection against oxidative damage could support the function of OBFC1 by providing a less hostile environment for DNA repair mechanisms, where OBFC1 plays a crucial role. | ||||||
Oleuropein | 32619-42-4 | sc-286622 sc-286622A sc-286622B sc-286622C | 500 mg 1 g 10 g 100 g | $352.00 $520.00 $775.00 $6640.00 | 2 | |
Oleuropein is a phenolic compound found in olives and olive oil, known for its antioxidant properties. By reducing oxidative stress, oleuropein may indirectly enhance the stability and functionality of OBFC1 in its role in DNA damage recognition and signal transduction pathways. | ||||||