OATP1 Inhibitors
OATP1 inhibitors belong to a distinct chemical class of compounds that are known for their ability to interact with and modulate the activity of the organic anion transporting polypeptide 1 (OATP1) transporters. OATP1 is a family of membrane-bound transport proteins found in various tissues of the human body, including the liver, kidney, and intestine. These transporters play a crucial role in the absorption, distribution, and elimination of endogenous and exogenous compounds, including drugs and other xenobiotics. OATP1 inhibitors are designed to specifically target and bind to the OATP1 transporters, thereby inhibiting their transport function. By doing so, these inhibitors can alter the uptake and clearance of various substances that are normally transported by OATP1. Consequently, the modulation of OATP1 activity can have profound effects on the pharmacokinetics and disposition of drugs and other compounds in the body.
Researchers are keenly interested in OATP1 inhibitors due to their potential to affect drug-drug interactions, drug absorption, and overall pharmacokinetic profiles. The inhibition of OATP1 transporters may lead to changes in drug bioavailability, distribution to specific tissues, and the potential for drug accumulation in certain organs. As a class of compounds with specific interactions and effects on OATP1 transporters, OATP1 inhibitors hold promise for further exploration and research.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is known to inhibit OATP1-mediated drug uptake. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
An immunosuppressive drug used in organ transplantation and autoimmune disorders, cyclosporine can inhibit OATP1 transport function. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin is known to interact with OATP1 transport. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A bioactive compound found in turmeric, curcumin, has demonstrated inhibitory effects on GSTO1. | ||||||
Atorvastatin | 134523-00-5 | sc-337542A sc-337542 | 50 mg 100 mg | $257.00 $505.00 | 9 | |
A commonly prescribed statin agent in research used to lower cholesterol levels, atorvastatin is known to interact with OATP1 transporters. | ||||||
Pravastatin | 81093-37-0 | sc-222188 | 50 mg | $408.00 | 1 | |
Another statin drug used to reduce cholesterol levels, pravastatin can also inhibit OATP1. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $145.00 | 8 | |
A potent statin used for cholesterol management, rosuvastatin has been shown to interact with OATP1 transporters. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
An antimetabolite and immunosuppressive drug studied in the research of cancer and autoimmune diseases, methotrexate can inhibit OATP1 transport function. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
An active component of licorice root extract, glycyrrhizin has been identified as an inhibitor of OATP1. | ||||||