OAT6 Activators

Chemical activators of OAT6 include a variety of compounds that interact with the estrogen receptor pathway to modulate the protein's activity. Estrone, a natural estrogen, can activate OAT6 by binding to estrogen receptors, which in turn interact with the promoter regions of genes encoding this transporter, leading to increased activity. Similarly, the synthetic estrogen diethylstilbestrol activates OAT6 through a comparable mechanism, binding to estrogen receptors and potentially altering the transcription regulation of genes related to organic anion transport. Phytoestrogens like genistein and kaempferol also activate OAT6 by agonizing estrogen receptors, which results in the enhancement of the protein's transport activity due to an increase in gene expression. Chrysin, another partial agonist of estrogen receptors, follows a similar pathway leading to the transcriptional activation of OAT6.

Other chemicals that activate OAT6 do so through various pathways that also intersect with estrogen receptor signaling. Bisphenol A, for instance, enhances the functional activity of OAT6 by interacting with nuclear receptors, which then bind to genes encoding this transporter. Indole-3-carbinol and naringenin activate OAT6 by modulating the estrogen receptor pathway, resulting in increased protein activity due to enhanced gene expression. Compounds like resveratrol activate OAT6 through their influence on SIRT1 and AMPK pathways, which are known to interact with estrogen receptor signaling. Curcumin and ellagic acid exert their effects on OAT6 by impacting nuclear receptors and associated signaling pathways that influence the expression and function of organic anion transporters. Lastly, benzyl isothiocyanate can increase the activity of OAT6 by influencing cellular detoxification pathways, which in turn increases the demand for organic anion transporters.