OAT6 Activators
Chemical activators of OAT6 include a variety of compounds that interact with the estrogen receptor pathway to modulate the protein's activity. Estrone, a natural estrogen, can activate OAT6 by binding to estrogen receptors, which in turn interact with the promoter regions of genes encoding this transporter, leading to increased activity. Similarly, the synthetic estrogen diethylstilbestrol activates OAT6 through a comparable mechanism, binding to estrogen receptors and potentially altering the transcription regulation of genes related to organic anion transport. Phytoestrogens like genistein and kaempferol also activate OAT6 by agonizing estrogen receptors, which results in the enhancement of the protein's transport activity due to an increase in gene expression. Chrysin, another partial agonist of estrogen receptors, follows a similar pathway leading to the transcriptional activation of OAT6.
Other chemicals that activate OAT6 do so through various pathways that also intersect with estrogen receptor signaling. Bisphenol A, for instance, enhances the functional activity of OAT6 by interacting with nuclear receptors, which then bind to genes encoding this transporter. Indole-3-carbinol and naringenin activate OAT6 by modulating the estrogen receptor pathway, resulting in increased protein activity due to enhanced gene expression. Compounds like resveratrol activate OAT6 through their influence on SIRT1 and AMPK pathways, which are known to interact with estrogen receptor signaling. Curcumin and ellagic acid exert their effects on OAT6 by impacting nuclear receptors and associated signaling pathways that influence the expression and function of organic anion transporters. Lastly, benzyl isothiocyanate can increase the activity of OAT6 by influencing cellular detoxification pathways, which in turn increases the demand for organic anion transporters.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A can enhance the functional activity of OAT6 by interacting with nuclear receptors which then bind to promoter regions of genes encoding organic anion transporters, thus increasing the functional activity of OAT6. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a phytoestrogen, activates OAT6 through its agonistic effect on estrogen receptors which modulate the gene expression of various organic anion transporters, including OAT6, to enhance their transport activity. | ||||||
Diethylstilbestrol | 56-53-1 | sc-204720 sc-204720A sc-204720B sc-204720C sc-204720D | 1 g 5 g 25 g 50 g 100 g | $71.00 $287.00 $547.00 $1098.00 $2185.00 | 3 | |
Diethylstilbestrol, a synthetic estrogen, can activate OAT6 by binding to estrogen receptors that may alter the transcriptional regulation of organic anion transporters, hence increasing the activity of OAT6. | ||||||
Chrysin | 480-40-0 | sc-204686 | 1 g | $38.00 | 13 | |
Chrysin activates OAT6 by acting as a partial agonist of estrogen receptors, which can lead to the transcriptional activation of genes involved in the organic anion transport including those for OAT6, increasing its activity. | ||||||
Benzyl isothiocyanate | 622-78-6 | sc-204641 sc-204641A | 5 g 25 g | $47.00 $156.00 | 1 | |
Benzyl isothiocyanate can activate OAT6 through its influence on cellular detoxification pathways, wherein it increases the demand for organic anion transporters, thereby potentially increasing the activity of OAT6. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol activates OAT6 by modulating the estrogen receptor pathway, which includes the transcriptional activation of genes encoding organic anion transporters, thus increasing OAT6 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates OAT6 by enhancing the expression of genes encoding organic anion transporters through its action on SIRT1 and AMPK pathways, which are known to cross-talk with estrogen receptor signaling affecting OAT6 activity. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol activates OAT6 by binding to estrogen receptors, leading to the transcriptional upregulation of genes encoding organic anion transporters and thus increasing the functional activity of OAT6. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates OAT6 through its effect on nuclear receptors and associated signaling pathways that influence the expression and function of organic anion transporters, thus enhancing OAT6 functional activity. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid activates OAT6 by exerting an influence on the estrogen receptor-mediated gene expression which includes the genes encoding organic anion transporters, thereby facilitating an increase in OAT6 activity. | ||||||