OAT6 Antibody (D-5): sc-514966
- OAT6 Antibody (D-5) is a mouse monoclonal IgG2b OAT6 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 536-552 within a C-terminal extracellular domain of OAT6 of human origin
- OAT6 Antibody (D-5) is recommended for detection of OAT6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-OAT6 Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP is the preferred secondary detection reagent for OAT6 Antibody (D-5) for WB applications. This reagent is now offered in a bundle with OAT6 Antibody (D-5) (see ordering information below).
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OAT6 Antibody (D-5) is a mouse monoclonal IgG2b antibody that detects OAT6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OAT6 (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OAT6, also known as organic anion transporter 6, is a 555 amino acid multi-pass membrane protein that plays a crucial role in the uptake of estrone sulfate, a key steroid hormone involved in various physiological processes, including reproduction and metabolism. OAT6 is part of the larger organic anion transporter family, which is essential for the absorption, distribution, and excretion of a wide range of endogenous metabolites and exogenous compounds, such as drugs and toxins. Proper functioning of OAT6 is vital, as disruptions can lead to significant health issues, including renal and hepatic toxicity. Additionally, OAT6 is known to be inhibited by several compounds, including probenecid and benzoate, and may also function as an odorant transporter, highlighting its diverse roles in cellular transport mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OAT6 Antibody (D-5) References:
- Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. | Monte, JC., et al. 2004. Biochem Biophys Res Commun. 323: 429-36. PMID: 15369770
- Transport of estrone sulfate by the novel organic anion transporter Oat6 (Slc22a20). | Schnabolk, GW., et al. 2006. Am J Physiol Renal Physiol. 291: F314-21. PMID: 16478971
- Olfactory mucosa-expressed organic anion transporter, Oat6, manifests high affinity interactions with odorant organic anions. | Kaler, G., et al. 2006. Biochem Biophys Res Commun. 351: 872-6. PMID: 17094945
- Molecular insights into the structure-function relationship of organic anion transporters OATs. | Zhou, F. and You, G. 2007. Pharm Res. 24: 28-36. PMID: 17103332
- Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. | Rizwan, AN. and Burckhardt, G. 2007. Pharm Res. 24: 450-70. PMID: 17245646
- Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. | Kaler, G., et al. 2007. J Biol Chem. 282: 23841-53. PMID: 17553798
- Identification of six putative human transporters with structural similarity to the drug transporter SLC22 family. | Jacobsson, JA., et al. 2007. Genomics. 90: 595-609. PMID: 17714910
- Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination. | Truong, DM., et al. 2008. J Biol Chem. 283: 8654-63. PMID: 18174163
- Organic anion transporter 6 (Slc22a20) specificity and Sertoli cell-specific expression provide new insight on potential endogenous roles. | Schnabolk, GW., et al. 2010. J Pharmacol Exp Ther. 334: 927-35. PMID: 20519554
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OAT6 Antibody (D-5) | sc-514966 | 200 µg/ml | $316.00 | |||
OAT6 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-548808 | 200 µg Ab; 10 µg BP | $354.00 | |||
OAT6 Antibody (D-5) AC | sc-514966 AC | 500 µg/ml, 25% agarose | $416.00 | |||
OAT6 Antibody (D-5) HRP | sc-514966 HRP | 200 µg/ml | $316.00 | |||
OAT6 Antibody (D-5) FITC | sc-514966 FITC | 200 µg/ml | $330.00 | |||
OAT6 Antibody (D-5) PE | sc-514966 PE | 200 µg/ml | $343.00 | |||
OAT6 Antibody (D-5) Alexa Fluor® 488 | sc-514966 AF488 | 200 µg/ml | $357.00 | |||
OAT6 Antibody (D-5) Alexa Fluor® 546 | sc-514966 AF546 | 200 µg/ml | $357.00 | |||
OAT6 Antibody (D-5) Alexa Fluor® 594 | sc-514966 AF594 | 200 µg/ml | $357.00 | |||
OAT6 Antibody (D-5) Alexa Fluor® 647 | sc-514966 AF647 | 200 µg/ml | $357.00 | |||
OAT6 Antibody (D-5) Alexa Fluor® 680 | sc-514966 AF680 | 200 µg/ml | $357.00 | |||
OAT6 Antibody (D-5) Alexa Fluor® 790 | sc-514966 AF790 | 200 µg/ml | $357.00 | |||
OAT6 (D-5) Neutralizing Peptide | sc-514966 P | 100 µg/0.5 ml | $68.00 |