Nup37 Activators
Nup37, also known as Nucleoporin 37, is a protein that in humans is encoded by the NUP37 gene. It's a part of the nuclear pore complex (NPC), a massive assembly of proteins that spans the nuclear envelope and acts as a gateway for molecular traffic between the nucleus and the cytoplasm.The NPC is composed of around 30 different proteins, known as nucleoporins, and Nup37 is one of them. Nup37 is a component of the Nup107-160 subcomplex, which is a critical component of the NPC. This subcomplex plays key roles in NPC assembly, function, and positioning in the nuclear envelope.
By being a part of the NPC, Nup37 is involved in the regulation of the transport of molecules across the nuclear envelope. This includes the transport of RNA and proteins in and out of the nucleus, a critical process for cellular function.Nup37, as a part of the Nup107-160 subcomplex, is also implicated in mitotic spindle assembly and function, which are crucial for cell division. Thus, Nup37 might play a role in cell proliferation.Alterations in the NUP37 gene or the Nup37 protein could potentially disrupt the function of the NPC and thereby affect nuclear-cytoplasmic transport and cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B, an inhibitor of the nuclear export protein CRM1, can indirectly affect nuclear transport processes, potentially impacting Nup37. | ||||||
JNK Inhibitor XVI | 1410880-22-6 | sc-364745 | 10 mg | $350.00 | 5 | |
Importazole, an inhibitor of the nuclear import receptor importin-β, might indirectly influence Nup37 activity by altering nuclear transport. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin, known for its activity against parasitic infections, has been shown to disrupt nuclear transport, potentially affecting Nup37. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to increased cAMP levels, which may indirectly influence Nup37. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin, an mTOR inhibitor, affects various cellular processes including nuclear transport, potentially influencing Nup37. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132, a proteasome inhibitor, can affect various cellular processes, potentially having an indirect impact on Nup37 function. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride, known to inhibit GSK-3β and modulate the Wnt pathway, could have an indirect effect on Nup37. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
TSA, a histone deacetylase inhibitor, can modulate chromatin structure and thus indirectly affect Nup37's role in nuclear transport. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1, a BET bromodomain inhibitor, affects transcription regulation, potentially influencing Nup37-mediated nuclear transport. | ||||||