Nup107 Activators
NUP107, a critical component of the nuclear pore complex, is essential for the regulated exchange of molecules between the nucleus and cytoplasm. Its function can be influenced indirectly by compounds that affect nuclear transport, cell cycle progression, or cellular stress responses. Leptomycin B and Ivermectin, by targeting different aspects of nuclear transport machinery, might alter the functional dynamics of the nuclear pore complex, potentially influencing the demand or activity of NUP107. Similarly, inhibitors such as Wheat Germ Agglutinin, by nonspecifically blocking nuclear pores, could lead to changes in nuclear transport efficiency or regulation, indirectly affecting NUP107's role or stability.
Compounds that affect cellular stress responses or protein homeostasis, such as MG-132 [Z-Leu- Leu-Leu-CHO], Sodium (meta)arsenite, and clasto-Lactacystin β-Lactone, might also indirectly influence NUP107. By inducing cellular stress or affecting protein degradation, these compounds could alter the functional demand for nuclear transport or the turnover of nuclear pore components. Hsp90 inhibitors like Radicicol and Geldanamycin, known to affect protein complex assembly, could impact the stability or assembly of the nuclear pore complex, potentially affecting NUP107. Additionally, compounds like Rapamycin and Caffeine, which influence cell cycle and metabolism, might indirectly modulate the need for or expression of NUP107 in response to changes in cell growth or stress. Collectively, these compounds represent potential indirect strategies for influencing NUP107 activity or expression, reflecting the complex interplay of nuclear transport, cell cycle regulation, and cellular homeostasis in maintaining the function of the nuclear pore complex and its components. Each compound, by altering different aspects of cellular physiology, contributes to the potential modulation of NUP107, highlighting the interconnected nature of cellular structures and processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
Ivermectin has been shown to affect the importin α/β1 heterodimer, a key component of the nuclear import pathway. By altering nuclear import, it might indirectly influence the function or demand for nuclear pore components, including NUP107. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol is a heat shock protein 90 (Hsp90) inhibitor. By affecting Hsp90 activity, it might influence the assembly or stability of protein complexes, including possibly the nuclear pore complex and NUP107. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor affecting cell growth and metabolism. It could potentially influence cell cycle progression and nucleocytoplasmic dynamics, indirectly affecting the role of NUP107. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 [Z-Leu- Leu-Leu-CHO] is a proteasome inhibitor that can increase cellular levels of ubiquitinated proteins, inducing stress responses that might indirectly influence NUP107's role in the nuclear pore complex. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine affects various cellular signaling pathways, including those involving cell cycle regulation and DNA damage response. It might indirectly influence NUP107 activity or expression through these pathways. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to raise the pH in intracellular compartments like lysosomes, potentially affecting cellular homeostasis and protein trafficking, which might indirectly affect NUP107. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium (meta)arsenite induces oxidative stress and heat shock responses. It might affect the integrity or function of protein complexes, including the nuclear pore complex, potentially impacting NUP107. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, impacting protein secretion and processing. This might lead to altered NUP107 activity due to changes in cellular trafficking and organization. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is another Hsp90 inhibitor that can affect the stability and function of various protein complexes. Its influence on protein homeostasis might indirectly impact NUP107 within the nuclear pore complex. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
clasto-Lactacystin β-Lactone is known to inhibit proteasome activity. By influencing proteasomal degradation, it might indirectly affect the turnover or function of proteins, including those like NUP107 involved in nuclear transport. | ||||||