NT5C1B Activators
NT5C1B activators are chemicals that specifically target the cAMP-PKA pathway or other cellular pathways that influence purine metabolism. They do so either by directly increasing the levels of cAMP through inhibition of phosphodiesterase enzymes, as seen with Cilostazol and IBMX, or by activation of adenylate cyclase via various receptor pathways, like Forskolin and Epinephrine. Once cAMP is elevated, protein kinase A (PKA) becomes active and phosphorylates downstream proteins that are critical in purine metabolism, where NT5C1B plays a role. Additionally, some of these chemicals, like Staurosporine, activate other kinases such as protein kinase C (PKC), which can also influence purine metabolic pathways and thereby activate NT5C1B.
The focus is strictly on chemicals that either elevate cAMP levels, activate PKA or PKC, or influence calcium signaling, given their known role in the pathways where NT5C1B is active. For instance, chemicals like 8-Br-cAMP serve as membrane-permeable analogs of cAMP, ensuring that PKA activation occurs even under conditions where cellular uptake might be a limiting factor. Thus, all listed chemicals are tailored to the specific biochemical networks that can directly or indirectly result in NT5C1B activation.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits cAMP phosphodiesterase, leading to cAMP accumulation and activation of PKA. PKA phosphorylates substrates that modulate purine metabolism, thereby indirectly activating NT5C1B. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase to increase cAMP levels. Elevated cAMP activates PKA which then phosphorylates factors that promote purine catabolism, subsequently enabling NT5C1B. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Phosphodiesterase inhibitor that increases cAMP, leading to PKA activation. PKA activates enzymes involved in purine metabolism, indirectly enhancing NT5C1B activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Activates adenylate cyclase via beta-adrenergic receptors, elevating cAMP and thus PKA. This activation results in a chain of events that can include NT5C1B activation. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Adenosine receptor antagonist that elevates cAMP, subsequently activating PKA and enzymes in purine catabolism, which can include NT5C1B. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Phosphodiesterase inhibitor that elevates cAMP and activates PKA, influencing purine metabolism and thereby potentially activating NT5C1B. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Increases cGMP by inhibiting phosphodiesterase, potentially promoting pathways that can indirectly activate NT5C1B in purine metabolism. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Induces PKC, which can then activate substrates in purine metabolism, influencing NT5C1B. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
Membrane-permeable cAMP analog activating PKA, which then stimulates purine metabolism, indirectly influencing NT5C1B. | ||||||
L-phenylephrine | 59-42-7 | sc-295315 sc-295315A | 5 g 25 g | $177.00 $482.00 | 2 | |
Alpha-adrenergic agonist that can result in increased cAMP levels, subsequently activating PKA and factors in purine metabolism including NT5C1B. | ||||||