NPP6 Activators
The chemical class referred to as NPP6 Activators encompasses a diverse array of compounds primarily associated with lipid signaling and metabolism, each of which can modulate cellular signaling pathways and thereby indirectly influence the activity of NPP6. These chemicals range from bioactive lipids like sphingosine-1-phosphate and platelet-activating factor, which function through G protein-coupled receptor-mediated pathways, to components of cellular membranes such as cholesterol, which plays a structural role in modulating the physical properties of lipid rafts, thereby affecting the localization and function of proteins associated with these microdomains. Arachidonic acid and its derivatives, including prostaglandins, are also part of this group, acting as precursors or ligands for signaling pathways that govern inflammatory responses and other cellular processes.
In the cellular context, chemicals such as PMA and forskolin serve as activators of protein kinase C and adenylyl cyclase, respectively, both of which are central to a multitude of signaling cascades. Through the activation of PKC, PMA can influence phosphorylation events that alter protein function and interaction networks within the cell. Forskolin, by raising cAMP levels, engages with PKA signaling, affecting various aspects of cell physiology that can intersect with the regulation of NPP6. Ceramide and lysophosphatidic acid engage with sphingolipid and phospholipid signaling pathways, respectively, influencing processes such as apoptosis, cell growth, and differentiation, which are critical for the modulation of protein expression and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) is a bioactive lipid that acts through G protein-coupled receptors to initiate signaling cascades affecting cellular proliferation, survival, and differentiation. S1P signaling can influence the expression of various genes and proteins, potentially including NPP6, by modulating transcription factors or by affecting lipid raft composition and associated signaling domains. | ||||||
PAF C-16 | 74389-68-7 | sc-201009 sc-201009A | 5 mg 25 mg | $128.00 $294.00 | 10 | |
Platelet-activating factor is a potent phospholipid activator and mediator of many leukocyte functions, including platelet aggregation and degranulation. Its signaling can impact the expression and function of diverse sets of proteins within the cell, possibly including NPP6, by modulating phospholipid metabolism and related signaling pathways. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $26.00 $2754.00 $126.00 $206.00 $572.00 $86.00 | 11 | |
Cholesterol is a major component of cell membranes and lipid rafts, which are specialized membrane microdomains. By influencing membrane fluidity and lipid raft formation, cholesterol can indirectly affect the localization and function of proteins associated with these domains, potentially including NPP6. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $90.00 $235.00 $4243.00 | 9 | |
Arachidonic acid is a polyunsaturated fatty acid that serves as a substrate for the synthesis of eicosanoids, which are signaling molecules involved in inflammatory responses. The metabolism of arachidonic acid can lead to the formation of bioactive lipids that modulate various protein functions, which could potentially influence the activity of NPP6. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which phosphorylates a wide range of cellular proteins, affecting many aspects of cell function including growth, differentiation, and gene expression. Through PKC activation, PMA can modulate signaling pathways that may influence the function of proteins like NPP6. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic acid is a monounsaturated fatty acid that can affect cellular metabolism and signaling. It is integrated into cell membranes and can influence membrane fluidity and function, potentially affecting the activity and localization of associated proteins such as NPP6. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) is a bioactive lipid that functions as an autocrine and paracrine signaling molecule, influencing inflammation, vascular tone, and immune responses. PGE2 signaling through its receptors can lead to changes in cellular protein expression and activity, which may indirectly modulate the function of NPP6. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $114.00 $198.00 | ||
NADPH is a cofactor used in anabolic reactions, such as lipid and nucleic acid synthesis, and in the reduction of oxidative stress. Through its role in redox reactions and biosynthesis, NADPH can influence various cellular processes that might affect the activity of proteins like NPP6, especially in the context of lipid metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP can activate PKA, which subsequently can phosphorylate various proteins and influence multiple signaling pathways, potentially affecting the expression and function of NPP6. | ||||||