NPP6 Antibody (F-8): sc-373890
- NPP6 Antibody (F-8) is a mouse monoclonal IgG2a κ NPP6 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 53-81 within an N-terminal extracellular domain of NPP6 of human origin
- NPP6 Antibody (F-8) is recommended for detection of NPP6 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-NPP6 Antibody (F-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NPP6 Antibody (F-8). This work is in progress.
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NPP6 Antibody (F-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects NPP6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NPP6 (F-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NPP6, also known as ectonucleotide pyrophosphatase/phosphodiesterase family member 6, is a 440 amino acid protein that plays a crucial role in lipid metabolism as a choline-specific glycerophosphodiester phosphodiesterase. NPP6 is predominantly expressed in the brain and kidney, where NPP6 hydrolyzes various substrates, including lysophosphatidylcholine, which is important for cell signaling and membrane integrity. NPP6′s ability to preferentially hydrolyze lysophosphatidylcholine with polyunsaturated or short fatty acids highlights NPP6′s significance in maintaining cellular homeostasis and modulating inflammatory responses. The gene encoding NPP6 is located on human chromosome 4, a region associated with several genetic disorders, underscoring NPP6′s potential implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NPP6 Antibody (F-8) References:
- Exclusion of the Ellis-van Creveld region on chromosome 4p16 in some families with asphyxiating thoracic dystrophy and short-rib polydactyly syndromes. | Krakow, D., et al. 2000. Eur J Hum Genet. 8: 645-8. PMID: 10951528
- Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype. | Sommardahl, C., et al. 2001. Physiol Genomics. 7: 127-34. PMID: 11773599
- Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements. | Dobson, CM., et al. 2002. Proc Natl Acad Sci U S A. 99: 15554-9. PMID: 12438653
- Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family. | Sakagami, H., et al. 2005. J Biol Chem. 280: 23084-93. PMID: 15788404
- Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme. | Kalchman, MA., et al. 1996. J Biol Chem. 271: 19385-94. PMID: 8702625
- Common mutations in the fibroblast growth factor receptor 3 (FGFR 3) gene account for achondroplasia, hypochondroplasia, and thanatophoric dwarfism. | Bonaventure, J., et al. 1996. Am J Med Genet. 63: 148-54. PMID: 8723101
- Autosomal dominant postaxial polydactyly, nail dystrophy, and dental abnormalities map to chromosome 4p16, in the region containing the Ellis-van Creveld syndrome locus. | Howard, TD., et al. 1997. Am J Hum Genet. 61: 1405-12. PMID: 9399901
- Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases. | Singhrao, SK., et al. 1998. Exp Neurol. 150: 213-22. PMID: 9527890
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPP6 Antibody (F-8) | sc-373890 | 200 µg/ml | $316.00 | |||
NPP6 Antibody (F-8) AC | sc-373890 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NPP6 Antibody (F-8) HRP | sc-373890 HRP | 200 µg/ml | $316.00 | |||
NPP6 Antibody (F-8) FITC | sc-373890 FITC | 200 µg/ml | $330.00 | |||
NPP6 Antibody (F-8) PE | sc-373890 PE | 200 µg/ml | $343.00 | |||
NPP6 Antibody (F-8) Alexa Fluor® 488 | sc-373890 AF488 | 200 µg/ml | $357.00 | |||
NPP6 Antibody (F-8) Alexa Fluor® 546 | sc-373890 AF546 | 200 µg/ml | $357.00 | |||
NPP6 Antibody (F-8) Alexa Fluor® 594 | sc-373890 AF594 | 200 µg/ml | $357.00 | |||
NPP6 Antibody (F-8) Alexa Fluor® 647 | sc-373890 AF647 | 200 µg/ml | $357.00 | |||
NPP6 Antibody (F-8) Alexa Fluor® 680 | sc-373890 AF680 | 200 µg/ml | $357.00 | |||
NPP6 Antibody (F-8) Alexa Fluor® 790 | sc-373890 AF790 | 200 µg/ml | $357.00 | |||
NPP6 (F-8) Neutralizing Peptide | sc-373890 P | 100 µg/0.5 ml | $68.00 |