NPC1L1 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ezetimibe | 163222-33-1 | sc-205690 sc-205690A | 25 mg 100 mg | $96.00 $241.00 | 12 | |
Ezetimibe inhibits NPC1L1 directly by preventing the absorption of cholesterol in the small intestine. It binds to NPC1L1, limiting its function in cholesterol transport, thereby reducing cholesterol absorption. | ||||||
Imipramine | 50-49-7 | sc-507545 | 5 mg | $190.00 | ||
Imipramine inhibits NPC1L1 indirectly by disrupting the endocytic pathway. By altering endosomal trafficking, imipramine can affect the transport and processing of NPC1L1, leading to reduced cholesterol absorption. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
Lovastatin inhibits HMG-CoA reductase, indirectly affecting NPC1L1 by reducing the synthesis of cholesterol. Lower intracellular cholesterol levels result in decreased substrate availability for NPC1L1-mediated absorption. | ||||||
Amiodarone | 1951-25-3 | sc-480089 | 5 g | $318.00 | ||
Amiodarone inhibits NPC1L1 indirectly by altering membrane lipid composition. This disrupts the organization of lipid rafts, impacting the proper localization and function of NPC1L1 in cholesterol absorption. | ||||||
β-Sitosterol | 83-46-5 | sc-204432 sc-204432A | 10 g 25 g | $61.00 $217.00 | 5 | |
Sitosterol competitively inhibits NPC1L1 by acting as a cholesterol analog. Its structural similarity to cholesterol allows it to interfere with the binding and absorption of cholesterol by NPC1L1 in the small intestine. | ||||||
CHOLESTYRAMINE RESIN | 11041-12-6 | sc-507509 | 5 g | $210.00 | ||
Cholestyramine inhibits NPC1L1 indirectly by binding to bile acids in the intestine. This interrupts the enterohepatic circulation of bile acids, leading to increased hepatic conversion of cholesterol to bile acids and reduced NPC1L1 activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits NPC1L1 indirectly by modulating intracellular cholesterol trafficking. By influencing endocytic processes, genistein disrupts the proper localization and function of NPC1L1 in cholesterol absorption. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine inhibits NPC1L1 indirectly by reducing the expression of intestinal NPC1L1. Through transcriptional regulation, berberine decreases the levels of NPC1L1, leading to a subsequent reduction in cholesterol absorption. | ||||||
Nonaethylene glycol monododecyl ether | 3055-99-0 | sc-281106 sc-281106A | 50 g 100 g | $184.00 $321.00 | ||
Nonaethylene glycol monododecyl ether inhibits NPC1L1 indirectly by disrupting lipid rafts in the intestinal membrane. This alteration in membrane composition interferes with the proper localization and function of NPC1L1, reducing cholesterol absorption. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine inhibits NPC1L1 indirectly by modulating cellular calcium levels. By influencing calcium-dependent processes, nifedipine disrupts the proper localization and function of NPC1L1 in cholesterol absorption. | ||||||