NPC1L1 Activators
The chemical class of NPC1L1 activators encompasses a diverse array of compounds that intricately modulate the pathways associated with NPC1L1 activation, contributing to the absorption of cholesterol in the small intestine. Betulinic Acid emerges as a potent indirect activator by promoting the expression of NPC1L1 through the modulation of transcriptional factors. This enhancement at the transcriptional level ensures an increased synthesis of NPC1L1, facilitating efficient cholesterol absorption. Similarly, Kaempferol, a flavonoid, influences endosomal trafficking, ensuring the proper localization and function of NPC1L1. This indirect activation mechanism highlights the importance of cellular processes in regulating NPC1L1 activity. Ursodeoxycholic Acid, a bile acid derivative, represents another indirect activator by interacting with bile acids. Its influence on bile acid composition enhances cholesterol solubility, leading to increased absorption via NPC1L1. This connection underscores the significance of bile acids in the intricate process of cholesterol homeostasis. Compounds like Quercetin and Geniposide further contribute to NPC1L1 activation by modulating cellular cholesterol levels. Their impact on cholesterol transporters and pathways ensures heightened cholesterol availability, facilitating NPC1L1-mediated absorption.
Moreover, Ginsenoside Rh2 and Tauroursodeoxycholic Acid showcase indirect activation by influencing endosomal trafficking and bile acid composition, respectively. By enhancing endocytic processes or altering bile acid dynamics, these compounds contribute to the efficient localization and function of NPC1L1. The significance of cellular cholesterol levels in NPC1L1 activation is underscored by Alpha-Lipoic Acid and Butyrate. These compounds, by modulating cholesterol transporters and pathways, increase intracellular cholesterol availability, supporting NPC1L1-mediated absorption. In summary, the chemical class of NPC1L1 activators offers a nuanced understanding of the diverse molecular mechanisms underlying NPC1L1 activation. From transcriptional modulation to endosomal trafficking, bile acid interaction, and regulation of cellular cholesterol levels, each activator contributes uniquely to the intricate network regulating cholesterol absorption via NPC1L1.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid activates NPC1L1 indirectly by promoting the expression of NPC1L1. Through modulation of transcriptional factors, it enhances the transcription and synthesis of NPC1L1, leading to increased cholesterol absorption. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol activates NPC1L1 indirectly by influencing endosomal trafficking. By enhancing endocytic processes, Kaempferol facilitates the proper localization and function of NPC1L1, promoting efficient cholesterol absorption. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $52.00 $131.00 | 4 | |
Ursodeoxycholic Acid activates NPC1L1 indirectly by interacting with bile acids. Its presence alters the composition of bile acids, leading to increased cholesterol solubility and absorption via NPC1L1, supporting cholesterol homeostasis. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Cholic Acid activates NPC1L1 indirectly by regulating bile acid synthesis. By promoting the synthesis of bile acids, Cholic Acid ensures the availability of substrates for cholesterol absorption via NPC1L1, enhancing this process. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin activates NPC1L1 indirectly by influencing cellular cholesterol levels. Through modulation of cholesterol transporters and pathways, Quercetin increases cholesterol availability, facilitating efficient NPC1L1-mediated absorption. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
Lithocholic Acid activates NPC1L1 indirectly by interacting with bile acids. Its influence on bile acid composition enhances cholesterol solubility, promoting effective absorption via NPC1L1 and contributing to cholesterol homeostasis. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid activates NPC1L1 indirectly by promoting cellular cholesterol influx. Through modulation of cholesterol transporters and cellular pathways, Butyrate increases intracellular cholesterol levels, supporting NPC1L1-mediated absorption. | ||||||
20(S)- Ginsenoside Rh2 | 78214-33-2 | sc-394416 sc-394416A | 1 mg 10 mg | $90.00 $265.00 | ||
Ginsenoside Rh2 activates NPC1L1 indirectly by influencing endosomal trafficking. By enhancing endocytic processes, Ginsenoside Rh2 ensures the proper localization and function of NPC1L1, facilitating efficient cholesterol absorption. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic Acid activates NPC1L1 indirectly by interacting with bile acids. Its influence on bile acid composition enhances cholesterol solubility, supporting efficient absorption via NPC1L1 and contributing to cholesterol homeostasis. | ||||||
Geniposide | 24512-63-8 | sc-279180 sc-279180A | 10 mg 25 mg | $80.00 $90.00 | ||
Geniposide activates NPC1L1 indirectly by promoting the expression of NPC1L1. Through modulation of transcriptional factors, it enhances the transcription and synthesis of NPC1L1, leading to increased cholesterol absorption. | ||||||