NOXA Inhibitors
Common NOXA Inhibitors include, but are not limited to Gossypol CAS 303-45-7, ABT 737 CAS 852808-04-9, ABT-199 CAS 1257044-40-8, Obatoclax Mesylate CAS 803712-79-0 and HA14-1 CAS 65673-63-4.
NOXA inhibitors belong to a specific chemical class of compounds designed to target and inhibit the activity of the NOXA protein. NOXA, also known as Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1), is a member of the BH3-only protein family. These proteins play a critical role in regulating apoptosis, the programmed cell death process essential for maintaining tissue homeostasis and eliminating damaged or infected cells. NOXA, in particular, is known to interact with and neutralize anti-apoptotic proteins, leading to the activation of pro-apoptotic Bcl-2 family members and the initiation of apoptosis.
NOXA inhibitors work by specifically targeting the NOXA protein, disrupting its interactions with anti-apoptotic proteins and altering the balance between pro-apoptotic and anti-apoptotic signals. By doing so, these inhibitors may modulate the apoptotic response of cells, influencing their survival and fate under various conditions. Research into NOXA and its inhibitors is ongoing to unravel their precise mechanisms of action and explore their implications in regulating cellular apoptosis. The study of NOXA inhibitors represents a fascinating area of research, contributing to the understanding of the intricate control mechanisms governing cell survival and death.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $116.00 $230.00 | 12 | |
Natural product that inhibits NOXA (PMAIP1) and Bcl-2 family members, leading to the release of pro-apoptotic proteins BAK and BAX, triggering apoptosis in cancer cells. Used in research as a potential anti-cancer agent. | ||||||
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $204.00 | 54 | |
BH3 mimetic that targets Bcl-2 family proteins, including NOXA (PMAIP1). It competitively binds to anti-apoptotic proteins (e.g., Bcl-2, Bcl-XL), promoting apoptosis by activating pro-apoptotic proteins (e.g., BAK, BAX). | ||||||
ABT-199 | 1257044-40-8 | sc-472284 sc-472284A sc-472284B sc-472284C sc-472284D | 1 mg 5 mg 10 mg 100 mg 3 g | $118.00 $337.00 $520.00 $832.00 $1632.00 | 10 | |
Also known as Venetoclax. Selectively inhibits BCL-2, indirectly impacting NOXA (PMAIP1) by preventing its interaction with BCL-2, leading to apoptosis in cancer cells. | ||||||
Obatoclax Mesylate | 803712-79-0 | sc-364221 sc-364221A | 5 mg 10 mg | $96.00 $141.00 | ||
BH3 mimetic that inhibits Bcl-2 family proteins, including NOXA (PMAIP1), promoting apoptosis by activating pro-apoptotic proteins BAK and BAX in cancer cells. | ||||||
WEHI-539 | 1431866-33-9 | sc-507317 | 5 mg | $233.00 | ||
Small molecule inhibitor that targets Bcl-XL, indirectly affecting NOXA (PMAIP1) by preventing its binding to Bcl-XL and promoting apoptosis in cancer cells. | ||||||
HA14-1 | 65673-63-4 | sc-205911 sc-205911A | 5 mg 25 mg | $59.00 $209.00 | ||
BH3 mimetic that inhibits Bcl-2 family proteins, including NOXA (PMAIP1), promoting apoptosis in cancer cells by activating pro-apoptotic proteins BAK and BAX. | ||||||
TW-37 | 877877-35-5 | sc-361387 sc-361387A | 10 mg 50 mg | $200.00 $860.00 | 2 | |
Synthetic Bcl-2 family inhibitor, indirectly affecting NOXA (PMAIP1) by preventing its interaction with Bcl-2, leading to apoptosis in cancer cells. | ||||||
Sabutoclax | 1228108-65-3 | sc-472977 | 1 mg | $330.00 | ||
BH3 mimetic that targets Bcl-2 family proteins, including NOXA (PMAIP1), promoting apoptosis in cancer cells by activating pro-apoptotic proteins BAK and BAX. | ||||||