NOMO1 Activators
NOMO1, or Nodal modulator 1, is a protein that in humans is encoded by the NOMO1 gene. NOMO1 is part of a family of proteins that are involved in the modulation of signaling pathways crucial for embryonic development and cellular differentiation processes. The protein interacts with components of the Nodal signaling pathway, which is a subset of the transforming growth factor-beta (TGF-β) superfamily of growth and differentiation factors.Nodal signaling is essential for the establishment of left-right asymmetry in developing embryos and plays a significant role in mesoderm formation and patterning. NOMO1, as a modulator, is implicated in the regulation of this pathway, influencing the activity of Nodal and its related signaling molecules. It does so potentially by forming complexes with Nodal and other pathway components, thereby affecting the availability and activity of these signaling molecules.
The modulation of Nodal signaling by NOMO1 is significant because imbalances in this pathway can lead to developmental anomalies, including defects in left-right body axis patterning, heart development, and the formation of other organs. Therefore, NOMO1 is a critical regulator ensuring that Nodal signaling occurs with the appropriate intensity and duration during embryonic development.In addition to embryogenesis, NOMO1 and its associated signaling pathways may have roles in adult tissue homeostasis and disease. Dysregulation of TGF-β signaling pathways, including Nodal, has been implicated in various pathological conditions, including cancer, fibrosis, and cardiovascular diseases.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
An inhibitor of the TGF-β receptor, which could indirectly influence Nodal signaling and NOMO1. | ||||||
LY 364947 | 396129-53-6 | sc-203122 sc-203122A | 5 mg 10 mg | $107.00 $156.00 | 4 | |
A small molecule inhibitor of TGF-β type I receptor, potentially impacting Nodal signaling and NOMO1 function. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
An inhibitor of ALK5, ALK4, and ALK7, which are receptors involved in Nodal signaling, potentially influencing NOMO1. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Known to modulate various signaling pathways, potentially impacting NOMO1 and Nodal signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Influences various signaling pathways and could indirectly affect NOMO1 function. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Affects cell signaling and could potentially impact Nodal signaling pathways involving NOMO1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Involved in developmental processes, potentially influencing Nodal signaling and NOMO1. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
A BMP inhibitor, which might have cross-pathway effects impacting Nodal signaling and NOMO1. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Regulates gene expression and cellular processes, potentially impacting NOMO1. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences Wnt signaling and other pathways, potentially having indirect effects on NOMO1. | ||||||