NOL55 Activators
NOL55 activators represent a distinct chemical class designed to influence the activity of the enzyme known as NOL55. This enzyme plays a crucial role in the hydroxylation of specific proline residues, a post-translational modification critical for the stability and function of certain proteins. The activation of NOL55 involves various biochemical pathways that hinge on the availability and interaction of essential cofactors and substrates within the cell. For example, the presence of certain metal ions and organic molecules at the active site of the enzyme is a prerequisite for its catalytic action. These ions and molecules participate in the enzymatic turnover, facilitating the transfer of an oxygen atom to the target proline residue.
The mechanisms through which NOL55 activators promote enzyme function include the stabilization of iron in its ferrous state, which is necessary for the hydroxylation reaction. Moreover, activators ensure the presence of a reducing environment that is conducive to the maintenance of iron in its active form. The provision of substrates such as 2-oxoglutarate is also paramount, as it is consumed in the reaction cycle of the enzyme. Furthermore, activators can influence the metabolic pathways that intersect with the regulation of NOL55, impacting the enzyme's expression levels. The cellular concentrations of such activators can modulate the activity of NOL55 indirectly by affecting the metabolic and signaling pathways that control the synthesis and degradation of the enzyme itself. Collectively, these activators are integral to the fine-tuning of NOL55 activity, ensuring that it functions optimally under varying physiological conditions, thereby upholding the structural integrity of the proteins that depend on its enzymatic action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
Required for the enzymatic activity of prolyl hydroxylases as a cofactor. It helps to maintain the iron ion in a reduced state (Fe2+), which is essential for the hydroxylation of proline residues on collagen and could possibly activate NOL55. | ||||||
Ferrous Sulfate (Iron II Sulfate) Heptahydrate | 7782-63-0 | sc-211505 sc-211505A | 250 g 500 g | $72.00 $107.00 | ||
Serves as a source of iron, a necessary cofactor for prolyl hydroxylase enzymatic activity. Iron (Fe2+) is at the active site of the enzyme and participates directly in the hydroxylation reaction, which could possibly activate NOL55. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $32.00 $42.00 $62.00 $108.00 $184.00 $724.00 $2050.00 | 2 | |
A substrate for prolyl hydroxylases and required for the hydroxylation reaction. The enzyme uses this compound to transfer an oxygen atom to the proline residue, which could possibly activate NOL55. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $44.00 $74.00 $130.00 | ||
Related to the TCA cycle and could influence cellular metabolic status, potentially impacting prolyl hydroxylase expression, which could possibly activate NOL55. | ||||||
Fumaric acid | 110-17-8 | sc-250031 sc-250031A sc-250031B sc-250031C | 25 g 100 g 500 g 2.5 kg | $42.00 $56.00 $112.00 $224.00 | ||
Involved in the TCA cycle and can impact metabolic pathways and cellular oxygen sensing mechanisms that might affect prolyl hydroxylase expression, which could possibly activate NOL55. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
A plant amino acid that can chelate iron and inhibit prolyl 4-hydroxylase, potentially leading to a compensatory upregulation of other prolyl hydroxylases, which could possibly activate NOL55. | ||||||
Deferoxamine mesylate | 138-14-7 | sc-203331 sc-203331A sc-203331B sc-203331C sc-203331D | 1 g 5 g 10 g 50 g 100 g | $255.00 $1039.00 $2866.00 $4306.00 $8170.00 | 19 | |
An iron chelator that binds to free iron, potentially affecting the availability of iron for prolyl hydroxylases and could possibly activate NOL55 by influencing iron homeostasis. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt can mimic hypoxic conditions by stabilizing hypoxia-inducible factor (HIF), which could lead to upregulation of prolyl hydroxylases under certain conditions, and could possibly activate NOL55. | ||||||
Pyruvic acid | 127-17-3 | sc-208191 sc-208191A | 25 g 100 g | $40.00 $94.00 | ||
A key metabolite in cellular energy pathways that might influence cellular conditions affecting prolyl hydroxylase activity, and could possibly activate NOL55. | ||||||
Citric Acid, Anhydrous | 77-92-9 | sc-211113 sc-211113A sc-211113B sc-211113C sc-211113D | 500 g 1 kg 5 kg 10 kg 25 kg | $49.00 $108.00 $142.00 $243.00 $586.00 | 1 | |
A central compound in the TCA cycle that influences metabolism; changes in citrate levels could have downstream effects on enzyme expression, which could possibly activate NOL55. | ||||||