nm23-H2 Activators
The term nm23-H2 Activators denotes a class of chemicals that modulate the activity of the nm23-H2 protein, which is also known as non-metastatic cells 2, protein expressed in (nucleoside-diphosphate kinase B). This enzyme is a pivotal member of the NM23 gene family, implicated in a variety of cellular undertakings such as DNA repair, development, and energy metabolism. The nature of its function largely relies on interactions with various molecules within the cell, and its enzymatic activity is tied to its role as a nucleoside-diphosphate kinase (NDPK). As such, activators within this class can interact directly or indirectly with nm23-H2, influencing its kinase activity, stability, or interaction with partner proteins.
The nm23-H2 Activators consist of a spectrum of molecules that range from substrates to cofactors, each contributing to the enzyme's functional landscape in unique ways. For instance, oligomeric ATP or ADP, as the substrates for NDPKs, might bolster nm23-H2 activity. Similarly, GTP analogs like GTPγS can be instrumental in probing nm23-H2's interaction with GTP, providing insights into its mechanistic underpinnings. The role of divalent cations such as magnesium and calcium ions cannot be understated; these ions often act as essential cofactors, modulating nm23-H2 activity. Reactive Oxygen Species (ROS) and other oxidative stress markers might indirectly influence nm23-H2, given that cellular redox states can affect a multitude of proteins. Furthermore, compounds like nucleoside analogs, phosphatase inhibitors, and kinase inhibitors, although not specific to nm23-H2, can still impact its activity indirectly by perturbing the surrounding molecular network in which nm23-H2 operates. Lastly, metal chelators and oxidative phosphorylation modulators offer insights into the enzyme's function in energy metabolism, given that its role straddles both nucleotide conversion and broader cellular energy dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $45.00 $68.00 $160.00 $240.00 $410.00 | 3 | |
Magnesium ions play a critical role in ATP stabilization and are essential for ATPases. As nm23-H2 possesses NDP kinase activity, reliant on ATP, magnesium sulfate can enhance nm23-H2's enzymatic activity by stabilizing ATP. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc ions are vital cofactors for many enzymes. They can activate nm23-H2 by facilitating proper protein folding and enhancing its structural stability, thus promoting its enzymatic activity related to nucleotide metabolism. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese ions act as essential cofactors for various enzymes, including kinases. Manganese(II) chloride can activate nm23-H2 by serving as a cofactor, enhancing its kinase activity involved in phosphorylation processes. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper ions can activate enzyme functions by binding to proteins and affecting their conformation. Copper(II) sulfate might activate nm23-H2 by promoting its structural integrity and enzymatic activity. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
As a cofactor in redox reactions, NAD+ can indirectly activate nm23-H2 by participating in cellular energy metabolism, potentially enhancing the protein's ATP-related functions. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP, as the primary energy currency of the cell, can activate nm23-H2 by providing the necessary phosphate groups for its kinase activity, directly enhancing its function in nucleotide metabolism. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $65.00 $262.00 | 1 | |
Calcium ions are crucial secondary messengers in numerous signaling pathways. Calcium chloride can activate nm23-H2 indirectly by modulating signaling pathways that enhance nm23-H2's activity. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $45.00 $56.00 $183.00 | 142 | |
As an inhibitor of protein tyrosine phosphatases, sodium orthovanadate can indirectly enhance nm23-H2 activity by modulating phosphorylation levels on proteins that interact with or regulate nm23-H2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels, which could indirectly activate nm23-H2 by stimulating pathways that enhance its phosphorylation and activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can lead to the activation of nm23-H2 through PKC-mediated signaling pathways that influence nm23-H2's phosphorylation state and activity. | ||||||