Nkx-2.2 Inhibitors
Nkx-2.2 Inhibitors constitute a diverse repertoire of compounds intricately designed to modulate the complex regulatory network governing Nkx-2.2 activity. This transcription factor plays pivotal roles in various developmental processes, interacting with Wnt, BMP, Hedgehog (Hh), and TGF-β signaling pathways. The inhibitors selected for this category exhibit specific mechanisms of action targeting these pathways, ultimately influencing Nkx-2.2 and the cellular processes it orchestrates. IWP-2, a Wnt pathway inhibitor, hinders the Wnt/β-catenin cascade critical for pancreatic development influenced by Nkx-2.2. By blocking Wnt signaling, IWP-2 indirectly inhibits Nkx-2.2, disrupting the intricate balance required for proper cellular responses. LDN-193189 and DMH1, BMP signaling inhibitors, act by targeting BMP type I receptors. Nkx-2.2, implicated in neural development influenced by BMP signaling, experiences indirect inhibition as these compounds disrupt the BMP pathway crucial for its activity.
Hedgehog pathway inhibitors, GANT-61 and Cyclopamine, play a significant role in modulating Nkx-2.2 during neural tube patterning. By blocking GLI transcription factors and Smoothened (SMO), respectively, these compounds indirectly inhibit Nkx-2.2, disrupting the normal progression of neural development. SIS3 and SB431542, targeting TGF-β/Smad signaling pathways, impact pancreatic and neural development, respectively. These inhibitors interfere with the TGF-β/Smad pathways, indirectly influencing Nkx-2.2 and highlighting the interconnectedness of signaling cascades in developmental processes. Each inhibitor selected exemplifies the precision required to modulate specific cellular processes associated with Nkx-2.2. The detailed biochemical and cellular mechanisms through which these inhibitors act provide valuable insights into the intricate regulatory networks that govern Nkx-2.2.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 inhibits Wnt signaling by blocking the Wnt/β-catenin pathway. Nkx-2.2 is involved in pancreatic development influenced by Wnt signaling, and inhibition of this pathway by IWP-2 can indirectly inhibit Nkx-2.2. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
Also called LDN-193189, this compound inhibits BMP signaling by targeting BMP type I receptors. As Nkx-2.2 is influenced by BMP signaling during neural development, inhibition of BMP by LDN-193189 can indirectly inhibit Nkx-2.2. | ||||||
GANT61 | 500579-04-4 | sc-202630 sc-202630A sc-202630B | 1 mg 5 mg 10 mg | $63.00 $128.00 $200.00 | 6 | |
GANT-61 inhibits Hedgehog (Hh) signaling by blocking the GLI transcription factors. Nkx-2.2 is part of the neural tube patterning influenced by Hh signaling, and GANT-61 can indirectly inhibit Nkx-2.2 by interfering with Hh pathway activity. | ||||||
SIS3 hydrochloride | 521984-48-5 | sc-253565 | 5 mg | $334.00 | 2 | |
SIS3 inhibits TGF-β/Smad3 signaling by blocking Smad3 phosphorylation. Nkx-2.2 is implicated in pancreatic development influenced by TGF-β signaling, and SIS3 can indirectly inhibit Nkx-2.2 by modulating the TGF-β/Smad3 pathway. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 inhibits Wnt signaling by promoting the degradation of β-catenin. As Nkx-2.2 is involved in pancreatic development influenced by Wnt signaling, XAV939 can indirectly inhibit Nkx-2.2 by reducing β-catenin levels and Wnt pathway activity. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $209.00 $312.00 $620.00 $1026.00 | 2 | |
DMH1 inhibits BMP signaling by targeting BMP type I receptors. The inhibition of BMP by DMH1 can indirectly inhibit Nkx-2.2, as Nkx-2.2 is implicated in neural development influenced by BMP signaling. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits Hedgehog (Hh) signaling by blocking Smoothened (SMO). Nkx-2.2 is part of neural tube patterning influenced by Hh signaling, and Cyclopamine can indirectly inhibit Nkx-2.2 by disrupting Hh pathway activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 inhibits TGF-β/Activin/Nodal signaling by blocking the type I receptors. Nkx-2.2 is implicated in pancreatic development influenced by TGF-β signaling, and SB431542 can indirectly inhibit Nkx-2.2 by interfering with the TGF-β/Activin/Nodal pathway. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1-endo inhibits Wnt signaling by stabilizing Axin. Nkx-2.2 is involved in pancreatic development influenced by Wnt signaling, and IWR-1-endo can indirectly inhibit Nkx-2.2 by promoting the degradation of β-catenin and modulating Wnt pathway activity. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $94.00 $348.00 | 69 | |
BML-275 (Dorsomorphin) inhibits BMP signaling by targeting BMP type I receptors. The inhibition of BMP by Dorsomorphin can indirectly inhibit Nkx-2.2, as Nkx-2.2 is implicated in neural development influenced by BMP signaling. | ||||||