Nir2 Activators
Nir2, also known as PITPNM1 (Phosphatidylinositol Transfer Protein, Membrane-Associated 1), is a protein encoded by the PITPNM1 gene in humans. It belongs to the large PITP (phosphatidylinositol transfer protein) family, which is involved in lipid transfer and metabolism.Nir2 primarily functions as a phosphatidylinositol transfer protein. It plays a crucial role in the maintenance of phosphatidylinositol 4,5-bisphosphate (PIP2) levels in the plasma membrane. PIP2 is a critical lipid molecule that acts as a precursor for secondary messengers involved in various cellular processes, including intracellular signal transduction, cytoskeleton organization, and membrane trafficking.
One unique aspect of Nir2's function is its role in the response to growth factor stimulation. Upon growth factor stimulation, PIP2 is hydrolyzed, and Nir2 is recruited from the cytoplasm to the plasma membrane. Here, Nir2 helps to replenish the levels of PIP2, ensuring sustained signaling and cellular responses.Nir2 is also involved in the endoplasmic reticulum (ER)-plasma membrane lipid exchange. It helps maintain ER structure and function and plays a role in the formation of lipid droplets, which are involved in lipid storage and metabolism.In summary, Nir2 is a critical protein involved in lipid transfer and metabolism, growth factor signaling, and maintaining ER function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which may lead to upregulation of Nir2 expression as part of signal transduction. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can affect inositol monophosphatase, potentially altering PI signaling and possibly Nir2 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
By increasing cAMP levels, forskolin can activate PKA signaling, which might influence Nir2 expression indirectly. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid regulates gene expression and might modulate Nir2 expression as part of its signaling effects. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin signaling affects a multitude of cellular processes including lipid metabolism, which could influence Nir2 expression. (Insulin is a protein, so this refers to insulin mimetics) | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, rapamycin may affect signaling pathways and gene expression profiles, including Nir2. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-DG is a glucose analog that interferes with glycolysis and could stress energy metabolism, potentially altering Nir2 expression. | ||||||