Nir2 Antibody (8): sc-136140

Nir2 Antibody (8) is a mouse monoclonal IgG1 kappa light chain antibody that detects Nir2 protein of mouse and rat origin by western blotting (WB) and immunoprecipitation (IP). Anti-Nir2 antibody (8) is available as non-conjugated format. Nir proteins, including Nir2, are human homologues of Drosophila retinal degeneration B (rdgB) and have been implicated as candidate genes for inherited retinal degeneration diseases. Nir2 is primarily localized in the Golgi apparatus during interphase, playing a crucial role in processing and trafficking proteins within cells. During cytokinesis, Nir2 is recruited to the cleavage furrow and midbody, highlighting its importance in cell division. Structurally, Nir2 features an amino-terminal phosphatidylinositol-transfer protein (PITP)-like domain, an acidic calcium-binding domain, six putative transmembrane domains, and a conserved carboxyl-terminal domain, suggesting involvement in calcium and phosphoinositide metabolism downstream of G-protein-coupled receptors. These unique localization and structural characteristics underscore Nir2′s essential function in cellular processes, making Nir2 a valuable target for research in retinal health and disease.

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Nir2 Antibody (8) References:

1. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta.  |  Fullwood, Y., et al. 1999. J Biol Chem. 274: 31553-8. PMID: 10531358
2. Nir2, a novel regulator of cell morphogenesis.  |  Tian, D., et al. 2002. Mol Cell Biol. 22: 2650-62. PMID: 11909959
3. Cellular and developmental distribution of human homologues of the Drosophilia rdgB protein in the rat retina.  |  Tian, D. and Lev, S. 2002. Invest Ophthalmol Vis Sci. 43: 1946-53. PMID: 12037004
4. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis.  |  Litvak, V., et al. 2002. Mol Cell Biol. 22: 5064-75. PMID: 12077336
5. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain.  |  Litvak, V., et al. 2002. Curr Biol. 12: 1513-8. PMID: 12225667

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nir2 Antibody (8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Nir2 Antibody (8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nir2 Antibody (8) Specifications

Alternate Product Name: Nir2

Product Clone Name: 8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 235-332

Epitope Target: Nir2

Epitope Species: mouse

Product Reactivity/Detection: Nir2

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Nir2 Antibody (8): N/A