NFU1 Inhibitors
Chemical inhibitors of NFU1 can interfere with the protein's function by disrupting its ability to synthesize and maintain iron-sulfur clusters, which are critical for its activity. Aurintricarboxylic Acid, Ciclopirox, Deferoxamine, Deferasirox, and Deferiprone are all iron chelators that bind to iron, thus sequestering this essential cofactor away from NFU1. Without adequate iron, NFU1 cannot catalyze the formation of iron-sulfur clusters, leading to its inhibition. These clusters are requisite for a variety of cellular processes, including mitochondrial electron transport, and their disruption has direct consequences on the functionality of NFU1. The binding of these molecules to iron reduces its bioavailability, preventing NFU1 from accessing the iron it requires to function normally.
Similarly, compounds like 2,2'-Bipyridyl, Mimosine, Bathophenanthroline, and Pyridoxal isonicotinoyl hydrazone act as iron chelators that inhibit NFU1 by depleting the cellular iron that is necessary for the biogenesis of iron-sulfur clusters. These chemical inhibitors ensure that iron does not become incorporated into these essential clusters, thereby halting the activity of NFU1. Tiopronin also contributes to the inhibition of NFU1 through its action as a chelator of heavy metals, including iron, which is crucial for the formation and maintenance of iron-sulfur clusters. Lastly, Triapine, while known to inhibit ribonucleotide reductase by chelating iron, similarly reduces the availability of iron for the assembly of iron-sulfur clusters, which in turn inhibits the function of NFU1. Each of these chemicals, by targeting the iron that is vital for NFU1's activity, can effectively inhibit the protein's function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aurintricarboxylic Acid | 4431-00-9 | sc-3525 sc-3525A sc-3525B sc-3525C | 100 mg 1 g 5 g 10 g | $20.00 $31.00 $47.00 $92.00 | 13 | |
Aurintricarboxylic Acid inhibits NFU1 by chelating iron, which is a cofactor necessary for NFU1 function in iron-sulfur cluster assembly. Without iron availability, NFU1 cannot catalyze the formation of these clusters that are vital for various enzymatic functions. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $250.00 | ||
Deferoxamine is an iron chelator that inhibits NFU1 by reducing the iron pool available for iron-sulfur cluster assembly. NFU1 relies on iron as a cofactor, and the absence of iron hampers its ability to participate in the maturation of these clusters, which are crucial for mitochondrial electron transport and other processes. | ||||||
Deferasirox | 201530-41-8 | sc-207509 | 2.5 mg | $176.00 | 9 | |
Deferasirox chelates iron, similar to other iron chelators, and limits the availability of iron required for NFU1's function in iron-sulfur cluster synthesis. The inhibition of iron-sulfur cluster formation by Deferasirox results in a direct inhibition of NFU1's enzymatic activity. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Mimosine chelates iron, thus inhibiting NFU1 by restricting iron availability for the biosynthesis of iron-sulfur clusters. With the functional impairment of NFU1 due to a lack of iron, the assembly of these clusters is disrupted, leading to inhibition of the protein's activity. | ||||||
Pyridoxal Isonicotinoyl Hydrazone | 737-86-0 | sc-204192 | 50 mg | $260.00 | 9 | |
Pyridoxal isonicotinoyl hydrazone is another iron chelator that can inhibit NFU1 by reducing the availability of iron for the synthesis of iron-sulfur clusters. With iron sequestered, NFU1's activity is inhibited as it cannot effectively participate in the assembly of these essential clusters. | ||||||
Triapine | 200933-27-3 | sc-475303 | 10 mg | $300.00 | ||
Triapine inhibits ribonucleotide reductase through iron chelation, and this mechanism also leads to the inhibition of NFU1 by reducing iron availability for iron-sulfur cluster assembly. NFU1 is functionally inhibited as it cannot perform its role in the synthesis of these clusters, whichIt seems there is no table provided that I should continue. If you have a specific table or list you'd like me to work on, please provide it and I will be happy to assist you. | ||||||