NFU1 Activators
Chemical activators of NFU1 can influence its function by contributing to the proper assembly and maintenance of iron-sulfur (Fe-S) clusters, which are vital for the protein's activity. Iron(II) sulfate and manganese(II) chloride serve as direct sources of metal ions, iron and manganese, respectively. These ions are integral to the Fe-S cluster assembly process that NFU1 facilitates. Iron is the primary metal component of these clusters, while manganese can act as a substitute, ensuring the formation and stability of the clusters, thereby supporting the activation of NFU1. Copper(II) sulfate and zinc sulfate further contribute to this process by delivering copper and zinc ions. Copper ions can stabilize Fe-S clusters, and zinc ions are crucial for maintaining the structural integrity of proteins like NFU1 that interact with these clusters. Additionally, selenium from selenium dioxide is beneficial for the function of Fe-S cluster-containing enzymes, indirectly supporting NFU1's role in their maturation.
Furthermore, nickel from nickel(II) sulfate can be incorporated into the Fe-S clusters. Its presence can enhance the formation and repair of these clusters, leading to the activation of NFU1. Cobalt(II) chloride supplies cobalt, which similarly can affect the assembly of Fe-S clusters. L-Cysteine, a sulfur-containing amino acid, provides sulfide necessary for the construction of Fe-S clusters, directly activating NFU1 by contributing to the biogenesis of these essential cofactors. Dithiothreitol (DTT) and 2-mercaptoethanol act as reducing agents that maintain the clusters in a reduced state, preventing protein aggregation and ensuring a conducive environment for NFU1 activity. Lastly, N-Acetyl-L-cysteine (NAC) offers cysteine while also protecting Fe-S clusters from oxidative damage with its antioxidant properties, thus maintaining the proper function and consequent activation of NFU1. Each of these chemicals plays a specific role in either the structural integrity, reduction-oxidation balance, or the synthesis of the Fe-S clusters that are crucial for NFU1's activation and function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Iron(II) sulfate solution | 10028-21-4 | sc-224024 | 1 each | $45.00 | ||
Iron(II) sulfate provides iron, which is a cofactor for NFU1 in the assembly of iron-sulfur clusters. This activation is critical for the function of NFU1 in mitochondrial electron transport and enzyme catalysis. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Manganese(II) chloride supplies manganese, a metal that can substitute for iron in iron-sulfur cluster assembly, which NFU1 is involved in. Manganese enhances the formation of these clusters, thereby activating NFU1. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $45.00 $120.00 $185.00 | 3 | |
Copper(II) sulfate can deliver copper, which plays a role in the stabilization of iron-sulfur clusters where NFU1 is active. By stabilizing these structures, copper can indirectly enhance NFU1 activity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc sulfate provides zinc ions that are essential for maintaining the structural integrity of proteins and enzymes. Since NFU1 is involved in iron-sulfur cluster biogenesis, zinc can activate NFU1 by ensuring proper protein conformation. | ||||||
Selenium | 7782-49-2 | sc-250973 | 50 g | $61.00 | 1 | |
Selenium dioxide contributes selenium, which is important for the function of certain iron-sulfur cluster-containing enzymes. It can activate NFU1 indirectly by participating in the maturation of these clusters. | ||||||
Nickel Sulfate | 7786-81-4 | sc-507407 | 5 g | $63.00 | ||
Nickel(II) sulfate supplies nickel, which can be incorporated into iron-sulfur clusters that NFU1 helps to assemble, thus potentially activating NFU1 by promoting cluster formation and function. | ||||||
L-Cysteine | 52-90-4 | sc-286072 sc-286072A sc-286072B sc-286072C sc-286072D | 25 g 100 g 500 g 5 kg 10 kg | $50.00 $110.00 $440.00 $1128.00 $2135.00 | 1 | |
L-Cysteine provides sulfide, a component of iron-sulfur clusters, which are crucial for NFU1 function. Supplying L-Cysteine activates NFU1 by contributing to the biogenesis of these clusters. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $63.00 $173.00 | 7 | |
Cobalt(II) chloride offers cobalt, which can influence iron-sulfur cluster assembly. Cobalt contributes to the activation of NFU1 by potentially enhancing the formation and repair of these clusters. | ||||||
β-Mercaptoethanol | 60-24-2 | sc-202966A sc-202966 | 100 ml 250 ml | $88.00 $118.00 | 10 | |
2-mercaptoethanol can maintain the iron-sulfur clusters in a reduced state, similar to DTT, and therefore activates NFU1 by ensuring the proper environment for cluster assembly and maintenance. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine is a source of cysteine and has antioxidant properties that can protect iron-sulfur clusters from oxidative damage, thus maintaining the proper function and activation of NFU1. | ||||||