NFATc4 Inhibitors
Common NFATc4 Inhibitors include, but are not limited to Cyclosporin A CAS 59865-13-3, FK-506 CAS 104987-11-3, Caffeic acid phenethyl ester CAS 104594-70-9, Glycyrrhizic acid CAS 1405-86-3 and (-)-Epigallocatechin Gallate CAS 989-51-5.
NFATc4 inhibitors represent a class of chemical compounds designed to target the activity of the nuclear factor of activated T cells isoform c4 (NFATc4). NFATc4 is a transcription factor that plays a pivotal role in regulating gene expression in response to intracellular calcium signaling and other signaling pathways. Inhibitors belonging to this class are intended to modulate the function of NFATc4, influencing its translocation to the nucleus, DNA binding, and subsequent transcriptional activity.
NFATc4 is a member of the NFAT family of transcription factors, which are primarily involved in immune response regulation and cellular processes like proliferation and differentiation. These inhibitors aim to disrupt the normal function of NFATc4 by dirupting its activation, which involves its dephosphorylation and translocation from the cytoplasm to the nucleus. By interfering with this process, NFATc4 inhibitors could impact the expression of target genes downstream of NFATc4 signaling, thereby influencing cellular responses in various contexts. The study of NFATc4 inhibitors contributes to a deeper understanding of the intricate mechanisms governing gene expression and cellular behavior, shedding light on avenues for further research into biological processes where NFATc4 is involved.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
A well-known immunosuppressive drug that inhibits the activity of calcineurin, preventing the dephosphorylation and activation of NFATC4, thus blocking its nuclear translocation and transcriptional activity. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Similar to Cyclosporine A, FK506 also inhibits calcineurin and suppresses the nuclear translocation of NFATC4, leading to reduced immune response. | ||||||
NFAT Inhibitor | 249537-73-3 | sc-507480 | 1 mg | $620.00 | ||
A modified version of the VIVIT peptide with enhanced cell permeability, effectively inhibiting NFATC4 activation. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
Derived from propolis, CAPE inhibits NFATC4 activation by blocking the calcineurin-NFATC4 interaction. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
A natural compound found in licorice, Glycyrrhizin inhibits NFATC4 by blocking the calcineurin pathway, leading to reduced NFATC4 nuclear translocation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol found in red wine, Resveratrol has been explored for its potential to inhibit NFATC4 activation and downstream immune responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A compound present in green tea, EGCG can inhibit NFATC4 activation by interfering with calcineurin-NFATC4 interactions. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Originally developed as a selective estrogen receptor modulator, Raloxifene has been investigated for its potential to inhibit NFATC4 activation and immune responses. | ||||||