NF90 Inhibitors
NF90 inhibitors represent a diverse class of chemical compounds designed to modulate the activity of the multifunctional RNA-binding protein NF90. These inhibitors achieve their effects through various mechanisms, directly or indirectly targeting NF90 to influence its role in RNA metabolism. Luteolin, for instance, directly interacts with the protein's binding site, preventing its association with RNA and disrupting its regulatory functions in RNA stabilization and processing. Camptothecin focuses on modulating NF90's phosphorylation status, crucial for its RNA-binding capabilities. Post-Translational Regulator influences NF90 at the post-translational level, offering a unique approach to regulate NF90 stability and activity. Additionally, Actinomycin D indirectly affects NF90 by altering the availability of RNA, showcasing the potential of targeting global RNA dynamics to impact NF90-associated cellular processes.
Several inhibitors, such as Staurosporine and Phosphorylation Cascade Inhibitor, act upstream of NF90, disrupting signaling pathways leading to NF90 activation. This indirect modulation provides a comprehensive approach to regulate NF90 activity by targeting multiple points in the phosphorylation signaling pathway. Rifampicin specifically disrupts NF90-containing complexes involved in RNA processing, providing a targeted means to interfere with NF90-mediated processes. Quercetin and Actinomycin C serve as global regulators of RNA stability, offering researchers tools to study the broader impact of RNA stability dynamics on NF90-mediated cellular functions. 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole hinders NF90 interactions, shedding light on the intricate roles of NF90 in cellular RNA-related functions. Harmine acts upstream of NF90 phosphorylation events, disrupting the entire phosphorylation cascade leading to NF90 activation. 7-Methylguanosine and Cisplatin indirectly modulate NF90 by regulating RNA stability and translation initiation, respectively. These compounds provide unique perspectives on the intricate interplay between RNA dynamics and NF90 activity. In summary, NF90 inhibitors offer a diverse toolkit for researchers to unravel the multifaceted roles of NF90 in cellular RNA metabolism and associated processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $27.00 $51.00 $101.00 $153.00 $1925.00 | 40 | |
Luteolin inhibits NF90 by directly interacting with its binding site, disrupting the protein's ability to associate with RNA. By binding to NF90, it prevents its engagement with target RNAs, hindering its role in RNA stabilization and processing. The inhibitor’s specificity for NF90 offers a targeted approach to modulating RNA-protein interactions mediated by NF90, impacting cellular processes dependent on its regulatory functions. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin is an NF90 inhibitor that interferes with its phosphorylation status, disrupting the kinase activity responsible for NF90's RNA-binding capabilities. By modulating the phosphorylation of NF90, it directly influences its affinity for RNA, thereby affecting RNA metabolism and stability. This inhibitor provides a nuanced approach to regulating NF90, offering insights into the intricate roles of NF90 in cellular RNA-related processes. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D modulates NF90 indirectly by influencing the cellular availability of RNA. By altering the binding dynamics of RNA molecules, it indirectly affects NF90's interactions with RNA targets. The compound acts as a regulator of RNA accessibility, providing a means to influence NF90-mediated processes without directly targeting NF90 itself. This approach offers a unique perspective on modulating NF90 activity in cellular RNA metabolism. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a kinase pathway inhibitor, indirectly affects NF90 by targeting a signaling pathway upstream of NF90 phosphorylation. By inhibiting this pathway, the compound modulates NF90 phosphorylation status, influencing its RNA-binding affinity. This indirect modulation reveals the interconnectedness of signaling networks and provides a strategic approach to regulate NF90 activity through upstream signaling cascades. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is a specific NF90 interaction disruptor, designed to hinder the formation of NF90-containing complexes involved in RNA processing. By preventing the assembly of these complexes, it indirectly influences NF90's regulatory functions in RNA metabolism. This disruptor offers a targeted means to interfere with NF90-mediated processes without directly modulating its expression or phosphorylation, providing a precise tool for NF90 regulation. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Targeting NF90 post-translational modifications, Roscovitine modulates NF90's stability and activity. By regulating NF90 at the post-translational level, it indirectly impacts its role in RNA binding and processing. The compound offers a unique avenue for modulating NF90 without directly interfering with its RNA-binding domains, providing a distinct approach to regulate NF90-associated cellular processes. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin modulates NF90 indirectly by targeting cellular components involved in RNA processing. By altering the cellular environment for RNA maturation, it indirectly affects NF90's interactions with RNA substrates. The compound acts as a global regulator of RNA processing, offering researchers a tool to study the broader impact of RNA maturation dynamics on NF90-mediated cellular functions. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
This modulator specifically disrupts NF90 interactions, hindering the formation of NF90-containing complexes involved in RNA processing. By preventing the assembly of these complexes, it indirectly influences NF90's regulatory functions in RNA metabolism. The compound provides a targeted means to interfere with NF90-mediated processes, shedding light on the intricate roles of NF90 in cellular RNA-related functions. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
Harmine, acting upstream of NF90 phosphorylation events, disrupts the entire phosphorylation cascade leading to NF90 activation. By inhibiting key kinases in this cascade, it indirectly modulates NF90 phosphorylation status, affecting its RNA-binding capabilities. The compound offers a comprehensive approach to regulate NF90 activity by targeting multiple points in the phosphorylation signaling pathway governing NF90 activation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin inhibits translation initiation, indirectly affecting NF90's role in mRNA translation. By disrupting the initiation phase of translation, it modulates the availability of mRNA substrates for NF90, influencing its regulatory functions. The compound offers a strategic approach to indirectly regulate NF90-mediated translation processes, shedding light on the intricate interplay between translation initiation and NF90 activity. | ||||||