NEURL1B Activators
NEURL1B, a neuralized E3 ubiquitin protein ligase 1B, plays a pivotal role in ubiquitin-dependent endocytosis, functioning as an E3 ubiquitin ligase within the actin cytoskeleton and cytosol. The protein is predicted to enable ubiquitin protein ligase activity, contributing to the regulation of endocytic processes. Activation of NEURL1B involves a complex interplay of various chemicals influencing ubiquitin-dependent endocytosis and the protein's localization within cellular compartments.
Ubiquitin-dependent endocytosis, a dynamic cellular process, is intricately regulated by NEURL1B through its ubiquitin ligase activity. Chemicals such as proteasome inhibitors, actin modulators, and endocytic pathway regulators impact NEURL1B directly or indirectly, leading to enhanced ubiquitin-dependent endocytosis and promoting NEURL1B activity. Actin dynamics, proteasome function, and endocytic vesicle formation are crucial aspects influenced by these chemicals, shaping NEURL1B's role in the intricate landscape of cellular processes. Understanding these general mechanisms provides valuable insights into potential strategies for manipulating ubiquitin-dependent endocytosis and NEURL1B activity, paving the way for further exploration of cellular regulatory networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132, a proteasome inhibitor, indirectly activates NEURL1B. Proteasome inhibition enhances ubiquitin-dependent endocytosis by stabilizing NEURL1B, promoting its activity as an E3 ubiquitin ligase within the actin cytoskeleton and cytosol. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride, an inhibitor of Na+/H+ exchanger, indirectly up-regulates NEURL1B. Inhibition of Na+/H+ exchanger influences endocytic pathways, positively impacting ubiquitin-dependent endocytosis and NEURL1B activity within the actin cytoskeleton and cytosol. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $229.00 | 29 | |
Latrunculin B, an actin depolymerizing agent, directly influences NEURL1B activity. Actin depolymerization disrupts NEURL1B's localization in the actin cytoskeleton, enhancing its translocation to the cytosol and promoting its ubiquitin ligase activity in ubiquitin-dependent endocytosis. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, indirectly activates NEURL1B. Proteasome inhibition enhances ubiquitin-dependent endocytosis by stabilizing NEURL1B, promoting its activity as an E3 ubiquitin ligase within the actin cytoskeleton and cytosol. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine, a calmodulin antagonist, indirectly stimulates NEURL1B. Calmodulin antagonism influences endocytic processes, positively impacting ubiquitin-dependent endocytosis and NEURL1B activity within the actin cytoskeleton and cytosol. | ||||||
Hydroxy-Dynasore | 1256493-34-1 | sc-364678 | 10 mg | $250.00 | ||
Hydroxy-Dynasore, a dynamin inhibitor, directly influences NEURL1B activity. Dynamin inhibition disrupts endocytic vesicle formation, enhancing ubiquitin-dependent endocytosis and promoting NEURL1B activity within the actin cytoskeleton and cytosol. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Jasplakinolide, an actin stabilizer, directly stimulates NEURL1B. Actin stabilization promotes NEURL1B localization within the actin cytoskeleton, enhancing its ubiquitin ligase activity and facilitating ubiquitin-dependent endocytosis in the cytosol. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Eeyarestatin I, an inhibitor of ERAD, indirectly up-regulates NEURL1B. ERAD inhibition influences endocytic processes, positively impacting ubiquitin-dependent endocytosis and NEURL1B activity within the actin cytoskeleton and cytosol. | ||||||
NSC697923 | 343351-67-7 | sc-391107 sc-391107A | 1 mg 5 mg | $15.00 $51.00 | 3 | |
NSC697923, a calpain inhibitor, indirectly activates NEURL1B. Calpain inhibition influences endocytic processes, positively impacting ubiquitin-dependent endocytosis and NEURL1B activity within the actin cytoskeleton and cytosol. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore, a dynamin inhibitor, directly influences NEURL1B activity. Dynamin inhibition disrupts endocytic vesicle formation, enhancing ubiquitin-dependent endocytosis and promoting NEURL1B activity within the actin cytoskeleton and cytosol. | ||||||