Date published: 2026-4-23

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NEPH1 Inhibitors

NEPH1 Inhibitors belong to a distinctive chemical class that plays a significant role in the field of molecular biology and cellular research. These inhibitors are designed to target NEPH1, a specific protein molecule that holds crucial importance in various cellular processes. NEPH1, also known as Nephrosis 1, is a transmembrane protein primarily found in the kidney's glomerular podocytes, but it has also been identified in other tissues and cell types throughout the body. This protein is part of a larger family of proteins known as nephrins, which are essential components of the glomerular slit diaphragm, a specialized structure in the kidney that is vital for maintaining the integrity of the blood filtration barrier.

NEPH1 Inhibitors are meticulously crafted molecules designed to interact with NEPH1 protein, modulating its activity and function within the cell. Researchers use these inhibitors as valuable tools to explore the intricate mechanisms underlying cellular adhesion, signal transduction, and cell-to-cell communication. By selectively blocking NEPH1, scientists gain insights into the role of this protein in various physiological and pathological processes. The study of NEPH1 Inhibitors also contributes to our understanding of the intricate interplay between different proteins within the nephron and the broader context of kidney function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein is a tyrosine kinase inhibitor that can affect phosphorylation events crucial for NEPH1 signaling and cellular junction formation.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a PI3K inhibitor that can disrupt downstream signaling pathways, which may influence NEPH1-mediated cellular processes.

PP 1

172889-26-8sc-203212
sc-203212A
1 mg
5 mg
$86.00
$145.00
6
(1)

PP2 is an Src family kinase inhibitor, which can hinder signaling pathways involving NEPH1-related kinases.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Dasatinib is a broad-spectrum tyrosine kinase inhibitor that can impact various signaling pathways, including those associated with NEPH1.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

SB203580 is a p38 MAPK inhibitor that can modify signaling events relevant to NEPH1-mediated cellular responses.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

U0126 is another inhibitor of MEK, which is upstream of ERK, and can affect NEPH1-related signaling processes.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

Y-27632 is a ROCK inhibitor that can affect cytoskeletal dynamics and cell junctions, potentially influencing NEPH1 function.

(S)-(−)-Blebbistatin

856925-71-8sc-204253
sc-204253A
sc-204253B
sc-204253C
1 mg
5 mg
10 mg
25 mg
$72.00
$265.00
$495.00
$968.00
(2)

Blebbistatin is a myosin II inhibitor that can disrupt cellular contractility and tension, processes relevant to NEPH1's role.